Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze |
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| Institution: | 1. Department of Pharmacology, School of Medicine, Campus USP, 14049-900, Ribeirão Preto, Brazil;2. Hebrew University, Pharmacy School, Jerusalem 91120, Israel [Fax 16-633-1586 or 16-633-1686];1. Sumy State University, Department of Pathology, Ukraine;2. Sumy State University, Ukraine;3. Sumy State University, Department of Orthopedics, Traumatology and Emergency Conditions, Ukraine;4. Sumy State University, Surgery Department with Pediatric Surgery and Urology, Ukraine;5. Sumy State University, Foreign Languages Department, Ukraine;1. Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil;2. Behavioural Neurosciences Institute (INeC), Av. do Café, 2450, Monte Alegre, Ribeirão Preto 14050-220, São Paulo, Brazil;3. Department of Neurosciences and Behavioural Sciences, Division of Psychiatry, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. dos Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil;4. Neurobiology of Emotions Research Centre (NAP-USP-NuPNE), Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. dos Bandeirantes, 3900, Ribeirão Preto, São Paulo 14049-900, São Paulo, Brazil |
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| Abstract: | - 1.1. In order to assess the presence of anxiolytic properties in cannabidiol (CBD) derivatives HU-219, HU-252 and HU-261, these drugs were tested in rats submitted to the elevated plus-maze model of anxiety.
- 2.2. Additional groups received diazepam or CBD. HU-219 (0.03-1 mg/kg) and CBD (5 mg/kg) significantly increased the percentage of open arm entries without changing the total number of entries, an anxiolytic-like effect.
- 3.3. Both HU-252 and HU-261 increased the percentage of time spent in open arms and the total number of entries, but only at the dose of 1 mg/kg.
- 4.4. Diazepam (2.5 mg/kg) increased both the percentage of entries and time spent on open arms and the total number of entries.
- 5.5. The results confirm previous findings with CBD and indicate that its derivative HU-219 may possess a similar anxiolytic-like profile.
- 6.6. Results from HU-252 and HU-261 are less apparent and suggest that the compounds may increase general exploratory activity in a limited range of doses.
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