Age-Related Changes in Human Blood Lymphocyte Subpopulations: II. Varying Kinetics of Percentage and Absolute Count Measurements |
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| Institution: | 1. Student Research Committee, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;2. Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran;3. Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;4. Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran;5. Department of Research and Development, Asian Jivan Teb Science-based Company, Sanandaj, Iran;1. Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON;2. The Ottawa Hospital Research Institute, Ottawa, ON;3. Faculty of Medicine, University of Ottawa, Ottawa, ON;4. Department of Obstetrics and Gynecology, McGill University, Montréal, QC;1. Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy;2. Diabetology Unit, Ospedale Misericordia e Dolce, Prato, Italy;3. Department of Epidemiology, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung & Blood Vessel Diseases, Anzhenli, Chaoyang District, Beijing 100029, PR China;1. Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China;2. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China;3. School of Mental Health, Jining Medical University, Shandong, Jining 272067, China;1. Service de Chirurgie Viscérale Mini-Invasive, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris Sud, Hôpital Béclère, Clamart, France;2. Service d’Endocrinologie et Diabétologie Pédiatrique & Médecine des Adolescents, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris Sud, Hôpital Bicêtre, Le Kremlin-Bicêtre, France |
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| Abstract: | A reference range for lymphocyte populations, with particular emphasis on T lymphocyte subsets, was obtained for normal individuals covering age cohorts from birth through adulthood. This report confirms and extends findings from a developmental reference range published earlier (1). Absolute numbers of WBC, lymphocytes, and T, B, and NK subsets decline significantly during childhood. However, differences in the rate of decline of certain lymphocyte subsets leads to discordance between absolute numbers and percentages. Those lymphocyte subsets which decline less rapidly with age than the total lymphocyte count will show an increase in percentage, whereas those which decline more rapidly will show further declines in percentage values. T cell percentages were seen to increase over time whereas B cell percentages decline. Markers of immaturity such as CD45RA on CD4 cells and CD38 on CD8 cells declined in both percentages and absolute numbers. Activation markers, such as HLA-DR on CD8 cells and IL2-R on CD3 cells, increased in percentages with time but changed inconsistently in cell number from infancy to adulthood. These findings extend the lymphocyte reference range to markers thought to be informative in various disease states, including HIV infection. |
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