Circulating markers in squamous cell carcinoma of the head and neck: A review |
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| Affiliation: | 1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China;2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China;1. Department of Cardiology, Southwest Hospital, Third Military Medical University, PR China;2. School of Medicine, Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia;3. Neuroscience Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia;1. Department of Civil and Environmental Engineering, University of Pittsburgh, 3700 O''Hara Street, 742 Benedum Hall, Pittsburgh, PA 15261, United States;2. Department of Chemical and Petroleum Engineering, University of Pittsburgh, 3700 O''Hara Street, 940 Benedum Hall, Pittsburgh, PA 15261, United States |
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| Abstract: | Biological markers of disease enhance the ability to diagnose, treat and evaluate results of therapy and are especially intriguing for their potential use in the management of malignant tumours. The serum levels of various biochemical substances have been shown to be abnormal for many cancers and are utilised in the management of affected patients. Several markers have been thoroughly investigated for potential clinical utility in head and neck carcinoma. Although no single marker has been found to be adequately sensitive and specific, combinations of markers may improve the utility for some aspects of patient management. This review highlights the literature to date in the realm of circulating markers for head and neck carcinoma. A discussion of the potential usefulness and limitations of such markers follows. |
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