Comparison of the action of the 5-HT2 antagonists amperozide and trazodone on preference for alcohol in rats |
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| Affiliation: | 1. Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA;2. Department of Applied Psychology, Guangdong University of Finance and Economics, Guangzhou, China;3. Laboratory of Applied Brain and Cognitive Sciences, College of International Business, Shanghai International Studies University, Shanghai, China;4. Department of Psychology, Sun Yat-Sen University, Guangzhou, China;5. Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA;6. School of Psychology, Southwest University, Chongqing, China;7. National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China;1. Department of Information Science and Technology, Dalian Maritime University, Dalian 116026, Liaoning, China;2. College of Information Science and Engineering, Ocean University of China, Qingdao 266100, Shandong, China;3. School of Computing Science and Engineering, VIT University, Vellore 632014, Tamil Nadu, India;1. University of Southern California, Los Angeles, CA, United States of America;2. Woods Hole Oceanographic Institution, Woods Hole, MA, United States of America;3. University of South Carolina, Columbia, SC, United States of America;4. Lamont-Doherty Earth Observatory, Palisades, NY, United States of America;5. University of Rochester, Rochester, NY, United States of America;6. University of Southern Mississippi, Hattiesburg, MS, United States of America;7. California Institute of Technology, Pasadena, CA, United States of America;1. School of Engineering, The University of Manchester, UK;2. Mechanical Engineering Department, System Reliability, Adaptive Structures, and Machine Acoustics, Technical University of Darmstadt, Otto-Berndt-Straße, Darmstadt, Germany |
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| Abstract: | Previous studies in the rat demonstrated that the 5-hydroxytryptamine2 (5-HT2) antagonist amperozide attenuates the volitional intake of both alcohol and cocaine solutions in a free-choice situation. However, another 5-HT2 antagonist, ritanserin, has not been found to reduce alcohol drinking consistently in the rat. In this study, trazodone was compared to amperozide for its effect on the volitional consumption of alcohol because, like amperozide, trazodone is a potent 5-HT2 receptor antagonist but a weak inhibitor of 5-HT reuptake. Male Sprague-Dawley rats were induced to drink alcohol by 10 mg/kg cyanamide injected for 3 days b.i.d. One week later the rats were offered a choice of water and increasing concentrations of alcohol solutions ranging from 3% to 30% v/v in a three-bottle two-choice paradigm. After the concentration of alcohol that produced maximal daily intake was determined for each rat, trazodone or amperozide was injected b.i.d. SC in doses of 1.0 mg/kg or 2.5 mg/kg for three days. Whereas the higher dose of amperozide produced a significant, 55.6% decrease from pretreatment baseline of alcohol intake, trazodone did not alter alcohol preference at either the 1.0- or 2.5-mg/kg dose. These results are discussed in terms of whether the antagonism of 5-HT2 receptors by amperozide is critical to its attenuating effect on preference for alcohol solutions. |
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