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Utilising organs from hepatitis C virus PCR-positive donors in Western Australia |
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| Authors: | Peter Boan Jagadish Jamboti Michael Musk Melanie Lavender Jeremy P. Wrobel Felicity Lee Amit Shah Lynette A. Pereira J. Owen Robinson Ashley Irish |
| Affiliation: | 1. Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Western Australia, Australia;2. Department of Nephrology, Fiona Stanley Hospital, Perth, Western Australia, Australia School of Medicine, University of Western Australia, Perth, Western Australia, Australia School of Medicine, Curtin University, Perth, Western Australia, Australia;3. Advanced Lung Disease Unit, Fiona Stanley Hospital, Perth, Western Australia, Australia;4. Advanced Lung Disease Unit, Fiona Stanley Hospital, Perth, Western Australia, Australia Department of Medicine, University of Notre Dame Australia, Perth, Western Australia, Australia;5. Advanced Heart Failure and Cardiac Transplant Service, Fiona Stanley Hospital, Perth, Western Australia, Australia;6. Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Western Australia, Australia Department of Microbiology, Fiona Stanley Hospital, PathWest Laboratory Medicine Western Australia, Perth, Western Australia, Australia Department of Infectious Disease, Royal Perth Hospital, Perth, Western Australia, Australia;7. Department of Nephrology, Fiona Stanley Hospital, Perth, Western Australia, Australia |
| Abstract: | We transplanted six solid organs from three hepatitis C virus (HCV) polymerase chain reaction (PCR)-positive donors during 2018–2023. Recipients were treated with glecaprevir/pibrentasvir or sofosbuvir/velpatasvir for 4–12 weeks, with all six achieving sustained virological response without significant adverse events. As occurs in other jurisdictions, solid organ transplants from HCR PCR-positive donors can be safely utilised in Australia. |
| Keywords: | hepatitis C virus HCV transplantation donor-derived infection |