Changes in the distribution of geniculocortical projections following monocular deprivation in tree shrews |
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| Authors: | S.L. Florence V.A. Casagrande |
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| Affiliation: | 1. Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 U.S.A.;2. Department of Psychology, Vanderbilt University School of Medicine, Nashville, TN 37232 U.S.A.;1. Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA;2. Department of Psychiatry, University of Cambridge; & Cambridge and Peterborough NHS Foundation Trust (CPFT), UK;1. INSERM, UMR 1064, Nantes F-44093, France;2. CHU de Nantes, ITUN, Nantes F-44093, France;3. CIC biothérapie, Nantes F-44035, France;4. Biochemistry Laboratory, Nantes University Hospital, Nantes, France;5. Intensive Care Unit, Anesthesia and Critical Care Department, Nantes University Hospital, Nantes, France;6. Thérapeutiques Cliniques et Expérimentales des Infections, EA 3826 Nantes, France |
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| Abstract: | We examined changes in the percentages and distribution of labelled geniculate (LGN) cells following injection of HRP into the striate cortices of normal and monocularly deprived tree shrews. Results show that deprivation does not affect the percentage of labelled cells but does alter the distribution. The projection column of labelled cells is much narrower in deprived than in non-deprived layers suggesting that the axons of non-deprived LGN cells either extend across greater distances in cortex to reach the injection sites or have more peripheral terminal sites available for transport than deprived counterparts. This finding indicates that, although ocular input to tree shrew striate cortex is organized in the form of horizontal strips, not columns, binocular competition still results in alterations in the growth of geniculocortical axons. |
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| Keywords: | tree shrew lateral geniculate nucleus striate cortex monocular deprivation horseradish peroxidase |
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