拓朴替康治疗小细胞肺癌近期疗效观察

目的 观察枯扑替康治疗小细胞肺癌的疗效和毒副反应。方法 拓扑替康单药治疗剂量为1．2mg/m^2，联合剂量为1mg/m^2，静脉输注30分钟，连用5天，联合卡铂剂量为350mg/m^2，21天为一周期，连用2个周期评价疗效。结果 17例中CR1例，PR12例，有效率76．5％。初治的有效率为90％，复治的有效率为57．1％。3例脑转移的患者、2例PR。毒副反应主要为中性粒细胞及血小板减少，18例中17例有不同程度的中性粒细胞减少，其中达Ⅲ、Ⅳ度的13例，血小板达Ⅲ、Ⅳ度8例。结论 拓朴替康单药治疗复发小细胞肺癌疗效确切，联合卡铂治疗可以耐受，疗效增加。主要的毒副反应是中性粒细胞和血小板减少。

The Effect of Topotecan in the Treatment for Small Cell Lung Cancer

To observe the effect and toxicity of topotecan in the treatment for small cell lung cancer(SCLC).Topotecan alone was used to treat patients at a dose of 1.2mg/m2,and combined with CBP 350mg/m2 at a dose of 1.0mg/m2,daily 30 min iv infusion for 5 days.Treatment was repeated once every 3 weeks.At last 2 cycles were given.In 17 SCLC patients,there were 1 CR,12 PR,with an overall response rate of 76.5%.The response rate of patients with or without prior chemotherapy was 90% and 57.1%,respectively.In 3 patients with brain metastasis,there were 2 PR.The major toxicity were neutropenia and thrombocytopenia,which occurred in 13 and 8 cases,respectively.[Conclusion]Topotecan is an effective agent for single use in the treatment for recurrent SCLC,and it combined with CBP is tolerable and effective.The major toxicity is neutropenia and thrombocytopenia.