银杏达莫注射液治疗急性脑梗死61 例临床观察

目的观察银杏达莫注射液治疗急性脑梗死(ACI)的临床疗效及血液流变学变化。方法117例ACI患者随机分为治疗组和对照组,治疗组给予银杏达莫注射液20 ml加入生理盐水500 ml静脉点滴,每日1次;对照组给予复方丹参注射液20 ml加入生理盐水500 ml静脉点滴,每日1次;疗程20 d,并于治疗结束后分别进行神经功能缺损评分,评价临床疗效,并检测血液流变学指标,进行组内治疗前后比较和组间比较。结果治疗组总有效率明显高于对照组(P<0.05)。治疗组治疗后全血比粘度、血浆比粘度、红细胞聚集指数及血小板聚集率较治疗前均有明显改善(P<0.01),而对照组仅全血比粘度及红细胞聚集指数有明显改善(P<0.01,P<0.05);治疗后治疗组各项指标较对照组均有明显改善(P<0.05)。结论银杏达莫注射液治疗急性脑梗死临床疗效显著,血液流变学指标改善明显。

Clinical observation of ginkgo dipyridolum injection for treatment of 61 patients with acute cerebral infarction

Objective To observe therapeutic efficacy and change of blood rheolagy of ginkgo dipyridolum injection in treatment of acute cerebral infarction(ACI).Methods One hundred and seventeen patients with ACI were randomly divided into treatment group and control group.The treatment group was performed with 20 ml ginkgo dipyridolum injection plus 500 ml saline intravenously,once a day for 20 days.The control group was performed with 20 ml salvia miltiorrhiza compound injection plus 500 ml saline intravenously,once a day for 20 days.Scoring of neurologic impairment,clinical efficacy and indexes of blood rheology were observed and compared in two groups.Results Total effective rate in treatment group was obviously higher than that in control group(P<0.05).Whole blood specific viscosity,plasma specific viscosity,erythrocyte aggregation index and platelet aggregation rate post-treatment were predominantly better than those pre-treatment in treatment group(P<0.01).Whole blood specific viscosity and erythrocyte aggregation index were obviously improved in control group post-treatment compared to pre-treatment(P<0.01,P<0.05).After treatment,all indices in treatment group were better than those in control group(P<0.05).Conclusion The ginkgo dipyridolum injection for treatment of ACI is effectiveness,it may obviously improve the indexes of blood rheology.