| 丙烯酰胺与葡萄糖烯丙基酰胺共聚水凝胶的合成与释药性能研究 |
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| 引用本文： | 李凌冰,谭业邦,孟建文.丙烯酰胺与葡萄糖烯丙基酰胺共聚水凝胶的合成与释药性能研究[J].生物医学工程学杂志,2004,21(6):960-963. |
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| 作者姓名： | 李凌冰 谭业邦 孟建文 |
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| 作者单位： | 1. 山东大学,西校区药学院,药剂教研室,济南,250012
2. 山东大学,化学与化工学院,济南,250100 |
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| 基金项目： | 国家自然科学基金 (2 990 40 0 3 )，山东大学预研基金资助(2 13 10 0 5 13 10 0 81) |
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| 摘 要： | 用葡萄糖内酯与烯丙基胺反应制备了葡萄糖烯丙基酰胺单体 (AAG) ,然后与丙烯酰胺和亚甲基双丙烯酰胺共聚得到含糖结构的水凝胶。以阿司匹林为模型药物 ,制备水凝胶缓释骨架片。通过对Peppas经验式中n值的详细考察 ,研究阿司匹林在不同骨架片中的释放度。证实骨架片中药物的释放是随着糖基单体的含量增加而减少。
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| 关 键 词： | 含糖结构的水凝胶 合成 释药性能 |
Synthesis and the Drug Release Properties of Poly(acrylamide-co-glycosylallylamide) Hydrogels |
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| Lingbing Li,Yebang Tan,Jianwen Meng.Synthesis and the Drug Release Properties of Poly(acrylamide-co-glycosylallylamide) Hydrogels[J].Journal of Biomedical Engineering,2004,21(6):960-963. |
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| Authors: | Lingbing Li Yebang Tan Jianwen Meng |
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| Institution: | School of Pharmaceutics, Shandong University, Ji'nan 250012, China. cn-lbli@263.sina.com |
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| Abstract: | Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel. |
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| Keywords: | Sugar-based hydrogels Synthesize Drug release properties |
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