Docetaxel,oxaliplatin, and capecitabine combination chemotherapy for metastatic gastric cancer |
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Authors: | Luigi Di Lauro Patrizia Vici Franca Belli Silverio Tomao Silvia Ileana Fattoruso Maria Grazia Arena Laura Pizzuti Diana Giannarelli Giancarlo Paoletti Maddalena Barba Domenico Sergi Marcello Maugeri-Saccà |
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Institution: | 1. Division of Medical Oncology B, “Regina Elena” National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy 2. Division of Oncology, Spolverini Hospital, Ariccia, Italy 3. Oncology Unit, Department of Medical-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, Italy 4. Division of Oncology, Fiorini Hospital, Terracina, Italy 5. Division of Oncology, Toraldo Hospital, Tropea, Italy 6. Division of Biostatistics, “Regina Elena” National Cancer Institute, Rome, Italy 7. Scientific Direction, “Regina Elena” National Cancer Institute, Rome, Italy
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Abstract: | Background The incorporation of docetaxel into the cisplatin and fluorouracil backbone has been demonstrated to be an active combination in metastatic gastric cancer. Nevertheless, this regimen is burdened by nonnegligible toxicity. We hypothesized that replacing cisplatin and fluorouracil with oxaliplatin and capecitabine should be an active and safe option for metastatic gastric cancer patients. Methods In this phase II study, we tested the activity of docetaxel in combination with oxaliplatin and capecitabine (DOC) as a first-line treatment. DOC was administered as follows: docetaxel (60 mg/m2) and oxaliplatin (100 mg/m2) on day 1, and capecitabine (500 mg/m2) was administered orally twice daily given continuously, with cycles repeated every 3 weeks. The primary endpoint was the overall response rate. Results Forty-eight patients entered the study. All patients had metastatic disease (stage IV). None of the patients had previously received chemotherapy for advanced disease. Performance status was 0, 1, and 2 in 25, 58, and 17 % of patients, respectively; 13 patients (27 %) had adenocarcinoma of the gastroesophageal junction, and 29 patients (60.5 %) had two or more metastatic sites. The overall response rate was 52.1 %. Progression-free survival and overall survival were 6.9 and 12.6 months, respectively. The treatment was well tolerated with no treatment-related deaths. The most common grade 3–4 toxicity was neutropenia (41 %). Conclusions DOC is an effective and tolerated first-line treatment, and the lower dose of docetaxel and oxaliplatin used in this study compared with other similar regimens does not seem to hamper the antitumor activity. |
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