Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis |
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Authors: | J. P. De La Cruz S. Cámara M. A. Frutos F. Sánchez De La Cuesta |
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Affiliation: | (1) Department of Pharmacology and Therapeutics School of Medicine, University of Málaga, E-29080 Málaga, Spain;(2) Department of Nephrology, Hospital Carlos Haya, Málaga, Spain |
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Abstract: | Summary The antiproteinuric effect of the antiplatelet agent dipyridamole has been assessed after inhibiton of thromboxane B2 (TxB2) synthesis in 8 patients with confirmed membranous glomerulonephritis. There were three study periods, each of 30 days, and 45 days apart, namely a washout period, treatment with dipyridamole 300 mg/d, and dipyridamole 225 mg/d plus aspirin 150 mg/d. On Days 1 and 30 of each study period serum and urine creatinine, 24-h excretion of protein, creatinine clearance, platelet aggregometry on whole blood and serum TxB2 were measured. Treatment with dipyridamole alone or with aspirin produced significant inhibition of platelet aggregation and a fall in 24-h protein excretion; the latter amounted to 54% with dipyridamole alone and 56 % with dipyridamole plus aspirin (NS). Dipyridamole plus aspirin caused an 82 % reduction in serum TxB2. |
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Keywords: | Dipyridamole, Acetylsalicylic acid, Urinary protein excretion antiplatelet agents, platelet aggregation, thromboxane synthesis, glomerulonephritis |
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