羟苯磺酸钙对青光眼患者视神经的保护作用

目的:观察羟苯磺酸钙对眼压已经手术控制的青光眼患者的视神经保护作用。方法:选取本院2011-01/2012-02住院的原发性青光眼患者共78例89眼,按照数字表随机分为对照组和观察组,疗程6mo。观察治疗前后两组患者视力、视网膜平均感光度、眼压、视盘形态学的变化,以及评价疗效。结果:两组患者治疗前后视力、眼压、视盘形态学均无明显变化,差异无统计学意义。对照组患者治疗前后视网膜平均感光度无明显变化(14.75±5.17 vs 13.48±4.69),而治疗组患者经羟苯磺酸钙治疗,视网膜平均感光度明显改善(14.56±5.03 vs 18.9±5.77),差异有统计学意义(P<0.05),与对照组治疗后相比,差异亦有统计学意义(P<0.05)。对照组视网膜平均感光度改善率、稳定率、恶化率分别为10.3%,48.7%,41.0%;而观察组分别为64.1%,28.2%,7.7%,两组相比差异有统计学意义(P<0.05)。结论:羟苯磺酸钙能提高青光眼患者视网膜平均光敏感度,对眼压已控制的青光眼患者有视神经保护作用。

Clinical study on the optic nerve protection of calcium dobesilate in treating glaucoma

AIM:To observe the protective effect of calcium dobesilate on optic nerve of glaucoma patients whose intraocular pressure has been under control through operation.

METHODS: A total of 78 inpatients(89 eyes)with glaucoma in this hospital from January, 2011 to February, 2012 were enrolled. All patients were randomly divided into treatment group and control group with 6 months in a course. The visual acuity, visual field(mean sensibility, MS), and intraocular pressure were measured at the experiment onset and 6 months later to evaluate the clinical effect.

RESULTS: There were no statistically significant differences in the visual acuity, intraocular pressure between the two groups neither at the experiment onset nor after 6 months(P>0.05). The mean sensibility(MS)of the treatment group was obviously improved(14.56±5.03 vs 18.9±5.77, P<0.05)with statistically significant differences before and after the treatment, while the MS remained unchanged in the control group(14.75±5.17 vs 13.48±4.69). There are statistically significant difference between the treatment group and the control group. Compared to the ratio of improvement, stability, and deterioration in the control group(10.3%, 48.7%, 41.0%), the indexes were changed obviously in the treatment group(64.1%, 28.2%, 7.7%,P<0.05)with statistically significant difference between the two groups.

CONCLUSION:Calcium dobesilate can improve mean retinal sensitivity and protect the optic nerve in glaucoma patients whose intraocular pressure has been controlled.