血清及房水中IL-6水平与炎症性青光眼的相关性研究

目的:测定炎症相关性青光眼(简称炎症性青光眼)患者血清及房水中白细胞介素-6(IL-6)的水平,探讨IL-6在炎症性青光眼发生发展中的作用。方法:选取炎症性青光眼患者20例20眼作为试验组(A组),原发性慢性青光眼(原发性慢性开角型青光眼和原发性慢性闭角型青光眼)患者20例20眼作为高眼压对照组(B组),老年性白内障患者20例20眼作为正常对照组(C组)。采集三组患者血清及房水标本,通过电化学发光法分别检测血清与房水中IL-6的水平。结果:炎症性青光眼组、原发性慢性青光眼组、老年性白内障组血清IL-6水平分别为3.26±2.10,4.20±1.94,3.50±2.24pg/mL,差异无统计学意义(F=1.080,P=0.345)。炎症性青光眼组、原发性慢性青光眼组、老年性白内障组房水IL-6水平分别为293.77±38.72,135.27±32.72,115.80±29.97pg/mL,差异有统计学意义(F=164.86,P=0.000),炎症性青光眼组明显高于原发性慢性青光眼及老年性白内障组,差异有统计学意义(P<0.01;P<0.01),原发性慢性青光眼组与老年性白内障组相比,差异无统计学意义(P>0.05)。结论:炎症性青光眼患者房水IL-6水平的高表达与炎症反应密切相关,与高眼压状态无明显相关性。

Study of the correlation between inflammatory glaucoma and IL-6 levels in serum and aqueous humor

AIM: To discuss the role of interleukin-6(IL-6)in the development of inflammatory glaucoma by detecting the IL-6 levels in serum and aqueous humor of inflammatory glaucoma patients.

METHODS: Totally 20 patients(20 eyes)with inflammatory glaucoma were selected as experimental group, 20 patients(20 eyes)with primary chronic glaucoma(primary chronic angle-closure glaucoma and primary chronic open angle glaucoma)as the high intraocular pressure control group, and 20 senile cataract patients(20 eyes)as the normal control group. Three specimens of serum, aqueous humor in three groups were collected and aqueous IL-6 levels were measured through electrochemiluminescence.

RESULTS: The serum IL-6 levels in Inflammatory glaucoma group, primary chronic glaucoma group, senile cataract group were 3.26±2.10, 4.20±1.94 and 3.50±2.24pg/mL, respectively, which doesn't demonstrate statistically significant differences(F=1.080, P=0.345). The aqueous IL-6 levels in the Inflammatory glaucoma group, primary chronic glaucoma group and senile cataract group aqueous were 293.77±38.72, 135.27±32.72 and 115.80±29.97pg/mL, respectively, demonstrating statistically significant differences(F=164.86, P=0.000). The Inflammatory glaucoma group was found to be significantly higher than that in the primary chronic glaucoma and senile cataract group(P<0.01; P<0.01). Comparing the aqueous IL-6 levels in the primary chronic glaucoma group with that in the senile cataract group, the differences of it were not statistically significant(P>0.05).

CONCLUSION: High expression of IL-6 levels in aqueous humor of inflammatory glaucoma patients is closely associated with inflammation, but it has no significant correlation with high intraocular pressure.