| 氧化应激诱导视网膜神经节细胞凋亡的研究进展 |
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| 引用本文： | 司俊康,郭俊国,王兴荣. 氧化应激诱导视网膜神经节细胞凋亡的研究进展[J]. 国际眼科杂志, 2013, 13(12): 2424-2426 |
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| 作者姓名： | 司俊康 郭俊国 王兴荣 |
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| 作者单位： | 中国山东省济南市,山东中医药大学;中国山东省济南市,山东中医药大学眼科研究所;中国山东省济南市,山东中医药大学眼科研究所; 中国山东省济南市,山东中医药大学附属眼科医院 |
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| 基金项目： | 山东省中医药科技发展计划资助项目(No.2011-130) |
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| 摘 要： | 视网膜神经节细胞(retinal ganglion cells,RGCs)凋亡是青光眼、糖尿病视网膜病变、视神经炎等多种疾病过程中的一个重要环节。在这些疾病过程中,氧化应激参与诱导RGCs的凋亡。近年的实验研究发现抗氧化应激药物对RGCs有良好的保护作用。我们将近年来氧化应激诱导RGCs凋亡以及相关抗氧化应激药物的研究进展做一综述。
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| 关 键 词： | 视网膜神经节细胞 凋亡 氧化应激 |
| 收稿时间： | 2013-07-19 |
| 修稿时间： | 2013-11-10 |
Research advances of oxidative stress-induced apoptosis of retinal ganglion cells |
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| Jun-Kang Si,Jun-Guo Guo and Xing-Rong Wang. Research advances of oxidative stress-induced apoptosis of retinal ganglion cells[J]. International Eye Science, 2013, 13(12): 2424-2426 |
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| Authors: | Jun-Kang Si Jun-Guo Guo Xing-Rong Wang |
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| Affiliation: | Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China;Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China;Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China; Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China |
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| Abstract: | Apoptosis of retinal ganglion cells(RGCs)is an important step in the mechanism of a variety of diseases such as glaucoma, diabetic retinopathy, optic neuritis etc. In these diseases, oxidative stress induces the aopoptosis of RGCs. In recent years, many experimental studies have found that anti-oxidative stress drugs have a powerful protective efficacy in RGCs. This article reviewed the recent advances in the researches on oxidative stress-induced apoptosis of RGCs and related anti-oxidative stress drugs. |
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| Keywords: | retinal ganglion cells apoptosis oxidative stress |
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