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| 继发性甲状旁腺增生与钙敏感受体表达的相关性研究 | |
| 引用本文： | 胡苹,娄晋宁,王泰龄,姚力,花簪,张凌,庞春红,李纯.继发性甲状旁腺增生与钙敏感受体表达的相关性研究[J].诊断病理学杂志,2009,16(5). |
| 作者姓名： | 胡苹 娄晋宁 王泰龄 姚力 花簪 张凌 庞春红 李纯 |
| 作者单位： | 1. 北京中日友好医院,临床医学研究所,北京,100029 2. 北京中日友好医院,病理科,北京,100029 3. 北京中日友好医院,普外科,北京,100029 4. 北京中日友好医院,血透中心,北京,100029 |
| 摘 要： | 目的 探讨钙敏感受体(CaR)在继发性甲状旁腺功能亢进(SHPT)患者甲状旁腺组织中的表达及其在发病机制中的作用.方法 采用免疫组化二步法对14例继发性甲状旁腺增生及8例正常甲状旁腺的石蜡标本进行CaR检测.结果 14例甲状旁腺增生患者的切片中均可见到CaR阳性细胞,CaR阳性率平均为(20.816±3.41)%, 其中8例结节性增生(NH)的CaR阳性率平均为(16.75±1.38)%,6例弥漫性增生(DH)病例为(28.16±2.16)%.结论 CaR阳性表达的减少与甲状旁腺组织增生密切相关,甲状旁腺增生组织中的表达明显低于正常甲状旁腺组织;而在NH 和DH中,以NH组表达减少更为显著.慢性肾功能衰竭所导致的CaR抑制,是引起SHPT的重要原因. |
| 关 键 词： | 继发性甲状旁腺功能亢进 慢性肾功能衰竭 免疫组化 |
Expression of calcium sensing receptor related with secondary hyperparathyroidism |
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| HU Ping,LOU Jin-ning,WANG Tai-lin,YAO Li,HUA Zan,ZHANG Lin,PANG Chun-hong,LI Chun.Expression of calcium sensing receptor related with secondary hyperparathyroidism[J].Chinese Journal of Diagnostic Pathology,2009,16(5). | |
| Authors: | HU Ping LOU Jin-ning WANG Tai-lin YAO Li HUA Zan ZHANG Lin PANG Chun-hong LI Chun |
| Abstract: | Objective To investigate the expression of calcium sensing receptor (CaR) and its role in parathyroid proliferation. Method 14 cases of secondary hyperparathyroidism (SHPT) and 8 cases of normal parathyroid tissue were examined with immunohistochemical staining for CaR. Results CaR expression was viewed in each SHFT case. Average positive cell rate of CaR was 20.816 ± 3.41% in 14 cases of SHFT. Average positive cell rate of CaR was 16.75±1.38% in nodular hyperplasis (NH) and 28.16±2.16% in diffuse hyperplasia (DH). Conclusion Decreased expression of CaR is closely correlated with parathyroid cell proliferation. The CaR expression is significantly lower in SHFT than that in normal parathyroid tissue, and also lower in DH than NH. It is an important factor for the pathogenesis of SHFT in which CaR is inhibited by chronic renal failure (CRF). |
| Keywords: | CaR |
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