双参宁心胶囊对血栓性心肌缺血小型猪心室重构和室壁运动的影响

目的观察双参宁心胶囊对血栓性心肌缺血小型猪心室重构和室壁运动的改善作用。方法小型猪LAD经心导管介入自体血栓制备心肌缺血模型,喂饲双参宁心胶囊6d后,应用常规超声和组织多普勒成像技术,观察心脏形态、左心收缩和舒张功能及左心室壁运动的改变。结果各组造模给药6d后行超声检查,模型对照组小型猪心脏室壁变薄,心腔扩大,出现心室重构,室壁运动减弱,双参宁心胶囊可明显降低模型动物LVIDd、LVIDs、ESV、EDV和IVRT,增加EF、左室前壁心尖段的室壁运动速度和追踪距离。结论双参宁心胶囊可通过改善左室重构,增加左心做功,改善左心收缩和舒张功能,增加左心室壁运动,发挥抗心肌缺血的作用。

Effects of Shuangshen Ningxin capsule on ventricular remodeling and wall motion in myocardial ischemic miniature swine induced by thrombus

Aim To observe the improved effects of Shuangshen Ningxin capsule on ventricular remodeling and wall motion in myocardial ischemic miniature swine induced by thrombus.Methods Myocardial ischemic model miniature swine induced by self-thrombus via cardiac catheter in left anterior descending coronary artery(LAD)were administrated Shuangshen Ningxin capsule for 6 days.The changes of cardiac form,left heart systolic and diastolic function,left ventricular wall motion were observed by the technology of conventional ultrasound and Doppler tissue imaging.Results 6 days after myocardial ischemia and administration,miniature swine of model group showed ventricular wall thinning,chambers heart dilating,ventricle remodeling and wall motion weak,but Shuangshen Ningxin capsule obviously lowered left ventricular internal diameter at end-diastole(LVIDd),left ventricular internal diameter at end-systole(LVIDs),end-systolic volume(ESV),end-diastolic volume(EDV)and isovolumic relaxation time(IVRT),and increased ejection fraction(EF),tissue velocity and tissue trace of left ventricle anterior wall cardiac apex segment.Conclusion Shuangshen Ningxin capsule has anti-myocardial ischemia effect by improving left ventricular remodeling,increasing left cardiac work,improving left heart systolic and diastolic function and increasing left ventricular wall motion.