| 高原红细胞增多症患者T细胞亚群的观察 |
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| 引用本文： | 何美懿 宋济范. 高原红细胞增多症患者T细胞亚群的观察[J]. 高原医学杂志, 1997, 7(2): 22-24 |
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| 作者姓名： | 何美懿 宋济范 |
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| 作者单位： | 北京医院检验科(何美懿)，国家计生委科研所(宋济范)，青海省人民医院(闫英，周晶苹，褚以德) |
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| 摘 要： | 目的：为了研究高原红细胞增多症患者细胞免疫功能，对９例ＨＡＰＣ患者的Ｔ细胞亚群从平原到高原进行了动态观察；方法；本研究采用间接免疫劳光法测定Ｔ细胞亚群；结果：在高原ＡＨＰＣ患者的ＯＫＴ３＾＋细胞明显低于正常人组，而ＯＫＴ＾＋４／ＯＫＴ＾＋８比值与正常人组相比明显上升；ＨＡＰＣ患者进入平原
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| 关 键 词： | 高山病 高原 红细胞增多症 细胞免疫 T细胞亚群 |
OBSERVATION OF T CELL SUBSETS OF HIGH ALTITUDE POLYCYTHEMIA |
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| He Meiyi, et al. OBSERVATION OF T CELL SUBSETS OF HIGH ALTITUDE POLYCYTHEMIA[J]. Journal of High Altitude Medicine, 1997, 7(2): 22-24 |
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| Authors: | He Meiyi et al |
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| Abstract: | In order to study cellular immune function of high altitude polycythemia (HAPC),the T cell subsets in 9 cases of HAPC were observed by using kinetic detecting from high altitudeto plain. Method:The indirect immunofluorescent assay was used in the present study. Resucts:These results showed that in high altitude(2260m),the level of OKT3+ cells of HAPC was signif-icantly lower(P<0. 01)than that of normal population- The ratio value of OKT4+/OKT8+ in pa-tients with HAPC was significantly higher(P<0. 05) than that in normal person group. Byday 10after migrating from high altitude to plain(10m),the OKT3+ cell level of HAPC was significantlyrisen, and the ratio value of OKT4+/OKT8+ had a declinig tendency. Conclusion it is suggestedthat hypoxia probably is a cause for lower cellular immunity in HAPC,the disorder and imbalanceof cellular immune function perhaps take part in mechanisms for developing symptoms of HAPC. |
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| Keywords: | High altitude polycythemia (HAPC) Cellular immunity T Lymphocyte subsets |
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