| 肛管及肛门区尖锐湿疣组织中人乳头瘤病毒基因类型的研究 |
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| 引用本文： | 张金浩,耿建祥,樊志敏,徐文华,吴崑岚,陈建宁,赵雪,王小峰.肛管及肛门区尖锐湿疣组织中人乳头瘤病毒基因类型的研究[J].医学研究生学报,2011,24(11). |
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| 作者姓名： | 张金浩 耿建祥 樊志敏 徐文华 吴崑岚 陈建宁 赵雪 王小峰 |
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| 作者单位： | 1. 南京中医药大学第三附属医院全国肛肠医疗中心,南京,210001
2. 南京中医药大学第三附属医院病理科,南京,210001 |
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| 基金项目： | 南京市科技发展基金(200601060) |
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| 摘 要： | 目的高危型人乳头瘤病毒(high-risk human papillomavirus,HPV)感染是宫颈癌的主要致病原因,现已发现HPV感染可诱发人类的许多肿瘤和疣。文中旨在探讨南京地区肛管及肛门区尖锐湿疣(condyloma acuminata,CA)患者中HPV基因类型的感染情况及其临床意义。方法从86份肛管及肛门区CA石蜡组织标本中提取23种HPVDNA,采用基因扩增芯片技术对其组织进行23种HPV基因类型的检测,并对其患者进行临床病理资料分析。结果 86份肛管及肛门区CA患者组织标本中检出HPV阳性66例,感染率为76.74%(66/86),其中单一型的阳性检出率为56.98%(49/86);单一型的感染中HPV11型为26例,其阳性检出率为30.23%(26/86),是最主要的感染类型;其次HPV6型为23例,阳性检出率为26.74%(23/86);混合型HPV感染17例,阳性检出率为19.77%(17/86);其中HPV6+11型8例,占混合型感染的47.06%(8/17),是混合型感染的主要类型;其次是5例4种类型的混合感染,占混合型感染的29.41%(5/17)。结论 HPV11型、6型、6+...
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| 关 键 词： | 尖锐湿疣 人乳头瘤病毒 肛管及肛门区 基因类型 基因芯片技术 |
Genotypes of human papillomavirus in condyloma acuminata in the anal canal and anus |
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| ZHANG Jin-hao,GENG Jian-xiang,FAN Zhi-min,XU Wen-hua,WU Kun-lan,CHEN Jian-ning,ZHAO Xue,WANG Xiao-feng.Genotypes of human papillomavirus in condyloma acuminata in the anal canal and anus[J].Bulletin of Medical Postgraduate,2011,24(11). |
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| Authors: | ZHANG Jin-hao GENG Jian-xiang FAN Zhi-min XU Wen-hua WU Kun-lan CHEN Jian-ning ZHAO Xue WANG Xiao-feng |
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| Institution: | ZHANG Jin-hao1,GENG Jian-xiang2,FAN Zhi-min1,XU Wen-hua 2,WU Kun-lan1,CHEN Jian-ning2,ZHAO Xue2,WANG Xiao-feng1(1.National Treatment Center for Anal and Colorectal Diseases,2.Department of Pathology,The Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210001,Jiangsu,China) |
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| Abstract: | ] Objective It is well known that high-risk human papillomavirus(HPV) infection is the major cause of cervical cancer,and HPV infection can induce a variety of tumors and verruca warts in human.We studied the genotypes of HPV and their clinical characteristics in condyloma acuminate(CA) of the anal canal and anus in Nanjing area.Methods From the paraffin tissue samples from the anal canal and anus of 86 CA patients,we obtained and examined 23 types of HPV DNA by means of PCR and gene-chips technique,followe... |
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| Keywords: | Condyloma acuminata Human papillomavirus Anal canal and anus Genetype Gene-chip technique |
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