| 兔海水淹溺肺水肿肺Na~ -K~ -ATP酶和细胞色素氧化酶活性变化的图像定量分析(论著) |
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| 引用本文： | 王琰,董文度,赵增荣,袁驾南,张敏华,刘虹,徐根兴,谷俊.兔海水淹溺肺水肿肺Na~ -K~ -ATP酶和细胞色素氧化酶活性变化的图像定量分析(论著)[J].中华航海医学与高气压医学杂志,1998(2). |
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| 作者姓名： | 王琰 董文度 赵增荣 袁驾南 张敏华 刘虹 徐根兴 谷俊 |
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| 作者单位： | 海军医学高等专科学校细胞生物学研究室 |
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| 摘 要： | 目的：探究海水淹溺肺水肿（ＰＥ－ＳＷＤ）的典型症状及其病理生理变化。方法：通过向兔肺进行海水灌注诱导ＰＥ－ＳＷＤ。用细胞化学和图像定量分析方法测定兔肺组织Ｎａ＋－Ｋ＋－ＡＴＰ酶和细胞色素氧化酶（ＣＹＴＯ）活性。结果：ＰＥ－ＳＷＤ组兔肺中，以上两种酶活性均显著降低。结论：酶活性的降低可能与淹溺造成肺组织缺氧有关，同时缺氧引起ＡＴＰ减少导致一系列肺组织代谢、功能与结构的变化，造成肺不张和ＰＥ－ＳＷＤ。
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| 关 键 词： | Na~＋－K~＋－ATP酶 细胞色素氧化酶 海水淹溺肺水肿 |
Image quantitative assay of Na K ATPase and cytochrome oxidase activity changes in lung tissue of rabbit with pulmonary edema after seawater drowning |
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| Wang Yan,Dong Wendu,Zhao Zengrong,et al..Image quantitative assay of Na K ATPase and cytochrome oxidase activity changes in lung tissue of rabbit with pulmonary edema after seawater drowning[J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine,1998(2). |
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| Authors: | Wang Yan Dong Wendu Zhao Zengrong |
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| Institution: | Wang Yan,Dong Wendu,Zhao Zengrong,et al.Naval Medical College,Nanjing 210099 |
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| Abstract: | Aim:To investigate the characteristic symptom and physiopathologic changes of pulmonary edema after seawater drowning(PE SWD) Methods:Sea water was infused into the rabbit's lung to induce PE SWD.Cytochemical and image quantitative assays were used to detected the Na K ATPase and cytochrome oxidase activities in the lung tissue.Results: the activities of the above mentioned two enzymes in the lung were shown decreased significantly after sea water infusing.Conclusion:The decrease of enzyme activities may be related to the anoxia of lung tissue caused by sea water infusion;and the ATP deficiency caused by anoxia resulted in a series of changes of metabolism,function and structure of the lung leading to atelectasis and PE SWD. |
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| Keywords: | Na K ATPase Cytochrome oxidase(CYTO) Pulmonary edema after seawater drowning(PE SWD) |
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