江苏地区HBV病毒基因分型及其临床意义

目的 探讨江苏地区HBV基因分型特点及临床意义.方法 对175例乙型肝炎(乙肝)患者血清进行基因分型.结果 江苏地区乙肝患者基因型以B型和 C型为主,分别为29.7%和65.1%.急性肝炎(AH),慢性肝炎(CH),活动性肝硬化(LC),重症肝炎(SH)和原发性肝癌(PHC)组的基因型构成比差别有统计学意义(P＜0.05).C型中LC所占的百分比显著高于B型(P＜0.01),而在CH组中B型所占的百分比显著高于 C型.基因C型患者HBeAg阳性率显著高于B型患者.结论 江苏地区HBV基因型以C型和B型为主,HBV基因B型常见于轻型肝病,C型和肝脏病情加重有一定关系.

HBV genotype and its clinical significance in Jiangsu district

Objective To investigate the distribution and clinical significance of hepatitis B virus (HBV) genotypes in Jiangsu district.Methods HBV gene sequencing analyses were conducted in 175 hepatitis patients from Jiangsu district. Results Most genotypes were B and C types (29.7% and 65.1%, respectively).Genotype distributing of acute hepatitis B, chronic hepatitis B, liver cirrhosis,severe hepatitis and hepatic cancer patients was significantly different.Liver cirrhosis was found more with genotype C than that with genotype B.Chronic hepatictis was more with genotype B than that with genotype C. HBeAg positive rate in patients of genotype C was higher than that of genotype B. Conclusion HBV genotype B and C are the major genotypes in Jiangsu district. Genotype B is found frequently in the patients with light hepatitis and genotype C is associated with the development of severe hepatitis B.