Quantifying the effects of iodine contrast media on standardised uptake values of FDG PET/CT images: an anthropomorphic phantom study |
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Authors: | Hairil Rashmizal Abdul Razak Abdul Jalil Nordin Trevor Ackerly Bruce Van Every Ruth Martin Moshi Geso |
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Institution: | (1) Discipline of Medical Radiations, School of Medical Sciences, Bundoora West Campus, RMIT University, VIC, 3083, Australia;(2) Nuclear Imaging Centre, Faculty of Medicine and Health Sciences, University Putra Malaysia (UPM), 43400 Serdang, Malaysia;(3) William Buckland Radiotherapy Centre, The Alfred Hospital, P.O. Box 315, Prahran, VIC, 3181, Australia;(4) Nuclear Medicine Department, The Alfred Hospital, P.O. Box 315, Prahran, VIC, 3181, Australia; |
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Abstract: | This study aimed to quantify the amount of change in Standardised Uptake Values (SUVs) of PET/CT images by simulating the
set-up as closely as possible to the actual patient scanning. The experiments were conducted using an anthropomorphic phantom,
which contained an amount of radioactivity in the form of Fluorodeoxyglucose (FDG) in a primary plastic test tube and one
litre saline bags, including the insertion of bony structures and another two test tubes containing different concentrations
of iodine contrast media. Standard scanning protocols were employed for the PET/CT image acquisition. The highest absolute
differences in the SUVmax and SUVmean values of the saline bags were found to be about 0.2 and 0.4, respectively. The primary
test tube showed the largest change of 1.5 in both SUVs; SUV max and SUVmean. However, none of these changes were found to
be statistically significant. The clinical literature also contains no evidence to suggest that the changes of this magnitude
would change the final diagnosis. Based on these preliminary data, we propose that iodine contrast media can be used during
the CT scan of PET/CT imaging, without significantly affecting the diagnostic quality of this integrated imaging modality. |
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