Total <Superscript>18</Superscript>F-dopa PET tumour uptake reflects metabolic endocrine tumour activity in patients with a carcinoid tumour期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Total 18F-dopa PET tumour uptake reflects metabolic endocrine tumour activity in patients with a carcinoid tumour

Authors:	Helle-Brit Fiebrich Johan R. de Jong Ido P. Kema Klaas Pieter Koopmans Wim Sluiter Rudi A.J.O. Dierckx Annemiek M. Walenkamp Thera P. Links Adrienne H. Brouwers Elisabeth G.E. de Vries

Affiliation:	(1) Department of Medical Oncology, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(2) Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(3) Department of Laboratory Medicine, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(4) Department of Endocrinology, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands

Abstract:	Purpose Positron emission tomography (PET) using 6-[¹⁸F]fluoro-L-dihydroxyphenylalanine (¹⁸F-dopa) has an excellent sensitivity to detect carcinoid tumour lesions. ¹⁸F-dopa tumour uptake and the levels of biochemical tumour markers are mediated by tumour endocrine metabolic activity. We evaluated whether total ¹⁸F-dopa tumour uptake on PET, defined as whole-body metabolic tumour burden (WBMTB), reflects tumour load per patient, as measured with tumour markers.

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