胺碘酮联合阿托伐他汀对阵发性房颤患者CRP和房颤复发率的影响

目的探讨胺碘酮联合阿托伐他汀对阵发性房颤患者CRP和房颤复发率的影响。方法 46例阵发性房颤患者随机分成研究组（给予胺碘酮＋阿托伐他汀治疗）和对照组（给予胺碘酮治疗）,每组各23例,随访1年。观察两组治疗前后CRP、左房内径和窦性心律维持率的变化。结果两组CRP较治疗前均有明显下降（P〈0.05）,组间比较差异亦有统计学意义（P〈0.05）;左房内径在治疗前后未发生显著变化（P〉0.05）;随访1年时,研究组窦性心律维持率明显高于对照组（P〈0.05）。结论阵发性房颤的发生与复发可能与炎症有关,胺碘酮联合阿托伐他汀可以有效降低CRP和房颤复发率。

The effect of amiodarone combined with atorvastatin on CRP and recurrence rate of atrial fibrillation for patients with paroxysmal atrial fibrillation

Objective To investigate the effect of amiodarone combined with atorvastatin on CRP and recurrence rate of atrial fibrillation for patients with paroxysmal atrial fibrillation.Methods 46 patients with paroxysmal atrial fibrillation were randomly divided into study group （given treatment of amiodarone combined with atorvastatin） and control group （given treatment of amiodarone）,23 cases in each group,all patients got 1 year follow-up visit.The change of CRP,left atrial diameter,and sinus rhythm maintenance rates were observed after treatment.Results CRP of the two groups were significantly reduced （P0.05） after treatment,the difference between the two groups was also statistically significant （P0.05）;left atrial diameter before and after treatment had not changed significantly （P0.05）;the maintenance rate of sinus rhythm in study group was significantly higher than control group in 1 year after treatment （P0.05）.Conclusion The occurrence and recurrence of paroxysmal atrial fibrillation may be related to inflammation,amiodarone combined with atorvastatin can effectively reduce CRP and recurrence rate of atrial fibrillation.