血管性认知障碍不同亚型患者外周血中细胞因子的变化

目的观察血管性认知障碍(VCI)不同亚型患者外周血细胞因子白细胞介素1β(IL-1β)、白细胞介素6(IL-6)以及TNF-α浓度变化特征。方法选择血管性认知障碍非痴呆型(VCI-ND)患者44例(VCI-ND组)、血管性痴呆(VaD)患者50例(VaD组)、混合型血管性痴呆(VCI-Mixed)患者47例(VCT-Mixed组),另选同期社区健康体检者40例(对照组),采用ELISA法测定各组血清IL-1β、IL-6和TNF-α,并进行比较。结果与对照组比较,VCI-ND组、VaD组和VCI-Mixed组IL-1β和TNF-α浓度明显增高(P<0.05)。与VCI-Mixed组比较,VCI-ND组和VaD组IL-6浓度明显增高(P<0.05)。结论炎性反应在VCI病理过程中广泛存在,以IL-1β和TNF-α增高为主要特征,而IL-6可能在缺乏阿尔茨海默病背景的VCI亚型中增高更为明显。

Changes of peripheral blood cytokines in patients with different vascular cognitive impairment subtypes

Objective To investigate the characteristics of changes of peripheral blood cytokines including IL-1β,IL-6 and TNF-α in patients with different vascular cognitive impairment(VCI) subtypes. Methods Forty-four patients with VCI no-dementia(group VCI-ND) ,50 patients with vascular dementia(group VaD) and 47 patients with mixed vascular dementia(group VCI-Mixed)were recruited. At the same time period, 40 individuals undergoing healthy examination were selected as control(group control). The serum levels of IL-1β,IL-6 and TNF-α were measured with ELISA kits and compared between different groups. Results IL-1β and TNF-α increased significantly in group VCI-ND, group VaD and group VCI-Mixed compared with group control (P<0.05). Furthermore, IL-6 augmented in group VCI-ND and group VaD compared with group VCIMixed (P<0.05). Conclusion The results suggest that inflammation is a common phenomenon in pathological process of VCI and the main characteristics are raised serum levels of IL-1β and TNF-α. However,the serum concentration of IL-6 may he dominant in VCI subtype without AD.