Cimetidine disposition in patients with Laennec's cirrhosis during multiple dosing therapy |
| |
Authors: | J P Cello S Øie |
| |
Institution: | (1) Gastroenterology Division, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA;(2) Department of Pharmacy, University of California, San Francisco, California, USA |
| |
Abstract: | Summary The disposition of cimetidine after oral and intravenous administration during multiple dosing was studied in 11 patients
with Laennec's cirrhosis. The average metabolic clearance of cimetidine in these patients was 151/h, similar to values reported
for normal subjects. However, in 4 subjects with plasma prothrombin times above normal, the metabolic clearance was significantly
decreased and ranged between 4.3 and 13.01/h. The renal clearance of cimetidine was proportional to the creatinine clearance
in all subjects, regardless of the severity of the liver disease. The clearance of cimetidine in patients with Laennec's cirrhosis,
therefore, appears to be predictabable from creatinine clearance and prothrombin time. |
| |
Keywords: | cimetidine alcoholic cirrhosis multiple dosing pharmacokinetics |
本文献已被 SpringerLink 等数据库收录! |
|