姜素预防犬运动病的效果观察

目的　观察姜素预防犬运动病的效果和对豚鼠视前庭相互作用的影响。　方法　采用随机双盲和安慰剂对照实验设计 ,观察 7 2mg/kg ,3 6mg/kg和 1 8mg/kg 3种剂量姜素及苯海拉明 (乘晕宁 3 2mg/kg)、盐酸苯环壬酯 (飞塞乐 0 2mg/kg)对犬运动病预防效果和对豚鼠视前庭系统的影响。犬运动病采用三角离心摆动方式 (峰速 2 4 0°/s ,频率 0 0 5Hz)诱发 ,以一定时间内犬的呕吐发生率作为犬运动病的观察指标 ;以正弦摆动 (峰速 6 0°/s,频率 0 0 5Hz)加光条刺激方式诱发豚鼠视前庭相互作用眼震 ,以眼震次数、慢相速度和增益作为视前庭相互作用观察指标。　结果　 3种剂量姜素均可显著降低犬呕吐发生率 ,且在 7 2mg/kg和 3 6mg/kg剂量时其效果较苯海拉明、盐酸苯环壬酯显著 ,各种药物对豚鼠VVOR眼震均无显著影响。　结论　姜素用于预防对抗运动病效果显著且不会影响正常的视前庭功能

Observations on prophylactic effects of ginger on motion sickness

Objective To study the prophylactic effects of ginger on motion sickness in canines and its influences on the vision vestibular interactions in guinea pigs Methods Using a double blind, placebo controlled design, effects of ginger extract in 3 dosages (7 8 mg/kg, 3 6 mg/kg and 1 8 mg/kg), theohydramine (3 2 mg/kg) and phencynonate hydrochloride (PCH) (0 2 mg/kg) on motion sickness (MS) in canines and VVOR in guinea pigs were examined Vomitting incidence was used as index for sensitivity of MS induced by eccentrical oscillation in a triangular velocity mode for 33 min, and beats, slow phase velocity and gain were used as indexes for evaluating vision vestibular interaction nystagmus induced by vertical oscillation with light strips surrounded Results As compared with placebo group, vomitting incidence in 3 ginger groups were significantly lower, and the vomiting incidences in 2 higher dosage (7 8 mg/kg, 3 6 mg/kg) ginger groups were significantly lower than those of theohydramine group and PCH group As compared with those of control group, no significant change of the indexes of VVOR in medication groups were found Conclusion It is suggested that ginger can be effectively used for prophylaxis of MS without significant effect on vision vestibular interaction