| 血栓调节蛋白在胃癌组织中的表达 |
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| 引用本文： | 明学志,尹浩然,朱正纲,薛建元,王瑞年,林言箴. 血栓调节蛋白在胃癌组织中的表达[J]. 中华实验外科杂志, 2000, 17(2): 143-144 |
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| 作者姓名： | 明学志 尹浩然 朱正纲 薛建元 王瑞年 林言箴 |
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| 作者单位： | 1. 200025,上海,第二医科大学附属瑞金医院外科
2. 上海第二医科大学病理学教研室 |
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| 摘 要： | 目的 研究血栓调节蛋白（ＴＭ）的胃癌组织中的表达。方法 应用免疫组织化学ＡＢＣ法对４０例手术切除胃癌标本进行ＴＭ表面的研究。结果 １８例肠型胃癌中，１５例ＴＭ表达阳性（８３．３％），２２例弥漫型胃癌中，１１例ＴＭ表达阳性（５０．０％）；６０岁以上病人是２３例，其中１９例ＴＭ表达阳性（８２．６％），６０岁以下病人１７例，其中７例ＴＭ表达阳性（４１．２％），肠型胃癌ＴＭ的表达明显高于弥漫型胃癌（Ｐ〈０
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| 关 键 词： | 血栓调节蛋白 基因表达 胃肿瘤 |
| 修稿时间： | 1999-02-20 |
Expression of thrombomodulin in gastric carcinoma |
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| MING Xuezhi ,YIN Haoran,ZHU Zhenggang,et al.. Expression of thrombomodulin in gastric carcinoma[J]. Chinese Journal of Experimental Surgery, 2000, 17(2): 143-144 |
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| Authors: | MING Xuezhi YIN Haoran ZHU Zhenggang et al. |
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| Affiliation: | MING Xuezhi *,YIN Haoran,ZHU Zhenggang,et al. *Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China |
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| Abstract: | Objective To study the expression of thrombomodulin (TM) in gastric carcinoma.Methods The expression of TM in 40 cases of gastric carcinoma was detected by means of immunohistochemical ABC.Results Among the 18 cases of gastric carcinoma of intestinal type, 15 were positive for TM (83.3%), 11 out of 22 cases of gastric carcinoma of diffuse type were positive for TM(50.0%), 19 of 23 gastric carcinoma patients over 60 years old were positive for TM (82.6%), 7 of 17 gastric carcinoma patients under 60 years old were positive for TM (41.2%), showing that the expression of TM in gastric carcinoma of intestinal type was significantly higher than that in gastric carcinoma of diffuse type, and that the expression of TM in gastric carcinoma patients over 60 years old was significantly higher than in those under 60 years old.Conclusion TM was overexpressed in gastric carcinoma of intestinal type as compared with that in gastric carcinoma of diffuse type. |
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| Keywords: | Thrombomodulin Gastric carcinoma Gene expression |
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