| 肾阳虚大鼠睾丸生精细胞凋亡相关基因的表达 |
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| 引用本文： | 李欣,李建团,付广莉.肾阳虚大鼠睾丸生精细胞凋亡相关基因的表达[J].承德医学院学报,2007,24(2):117-119. |
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| 作者姓名： | 李欣 李建团 付广莉 |
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| 作者单位： | 承德医学院,河北,承德,067000;承德医学院附属医院 |
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| 摘 要： | 目的:观察肾阳虚大鼠睾丸生精细胞凋亡相关基因bcl-2和bax表达的变化.方法:选用雄性SD大鼠,每日用腺嘌呤(200mg/kg)灌胃,连续30天,造成肾阳虚生精障碍模型大鼠.采用免疫组织化学方法观察bcl-2和bax的表达情况.结果:与正常大鼠比较,模型大鼠睾丸生精细胞bcl-2的表达显著下降、bax的表达显著增高(P＜0.05).结论:睾丸生精细胞凋亡相关基因bcl-2和bax表达的改变可能是肾阳虚大鼠生精障碍的原因之一.
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| 关 键 词： | 肾阳虚 生精障碍 bcl-2 bax |
| 文章编号： | 1004-6879（2007）02-0117-03 |
| 收稿时间： | 2006-12-14 |
| 修稿时间： | 2006-12-14 |
EXPRESSION OFAPOPTOSIS RELATED GENES OF SPERMATOGENIC CELLS IN SHENYANG DEFECTED RATS TESTIS |
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| Li Xin,Li Jian-tuan,Fu Guang-li.EXPRESSION OFAPOPTOSIS RELATED GENES OF SPERMATOGENIC CELLS IN SHENYANG DEFECTED RATS TESTIS[J].Journal of Chengde Medical College,2007,24(2):117-119. |
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| Authors: | Li Xin Li Jian-tuan Fu Guang-li |
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| Institution: | Chengde Medical College, Hebei Chengde 067000, China |
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| Abstract: | Objective: To observe the expression of apoptosis related genes bcl-2 and bax of spermatoge-nic cells in shenyang-defected rats testis.Methods: Male SD rats were applied in this study and adenosine (200mg/kg/d) was given to the rats to make shenyang-defected spermatogenesis disturbance model rats. Im-munohistochemistry was used to observe the expression of bcl-2 and bax of spermatogenic cells in testis. Results:Compared with normal rats, the expression of bcl-2 of spermatogenic cells in model rats testis was obviously decreased and the expression of bax was obviously increased (P<0.05). Conclusions:In Shenyang-defected rats, the changes of apoptosis related genes bcl-2 and bax maybe one of the reasons of spermatogenesis disturbance. |
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| Keywords: | bcl-2 bax |
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