| 影响尿液储存稳定性的常见因素 |
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| 引用本文： | 罗伊,王从容.影响尿液储存稳定性的常见因素[J].检验医学,2014(1):86-90. |
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| 作者姓名： | 罗伊 王从容 |
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| 作者单位： | 上海市糖尿病研究所上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病重点实验室上海市糖尿病临床医学中心代谢性疾病样本库,上海200233 |
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| 基金项目： | 国家自然基金面上项目（81170760）;国家科技部重大新药创制一代谢性疾病临床标本资源库建设（2011ZX09307-001-02）;上海市科委研发平台专项基金资助项目（12DZ2295004） |
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| 摘 要： | 尿液获取简便,能被无创性收集并能提供大量生理上变化发展进程的信息。尿液中存在许多潜在生物标记物,包括代谢物质、细胞、蛋白、核酸等。许多因素对尿液中的生物标记物产生一定的影响,诸如存储温度、存储时间、酸碱度、反复冻融等。而外在因素对尿液储存稳定性的影响仍存在争议。随着组学技术的发展,利用尿液开展代谢组和蛋白质组学分析也日益增多,进一步拓宽了外在因素影响尿液存储稳定性的研究。现就外界因素对尿液检测指标的影响情况及环境因素对尿液代谢组和蛋白质组学分析的影响情况做了综述。
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| 关 键 词： | 尿液 存储 稳定性 |
Common influence factors for the stability of urine storage |
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| LUO Yi,WANG Congrong.Common influence factors for the stability of urine storage[J].Laboratory Medicine,2014(1):86-90. |
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| Authors: | LUO Yi WANG Congrong |
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| Institution: | . ( Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People＇s Hospital, Shanghai Key Laboratory of Diabetes MeUitus, Shanghai Clinical Center for Diabetes, Metabolic Diseases Biobank, Shanghai 200233, China) |
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| Abstract: | Urine is easily accessible, can be collected noninvasively, and provides information on numerous physiological processes. Urine is a source of numerous potential biomarkers, including metabolites, cells, proteins and nucleic acids. Many factors can affect the quality of the stored urine, including the time and temperature of storage, PH and multiple freezing and thawing. However, it remains being a controversial topic on the influence of exterior factors on the stability of urine storage. With the development of proteomics and metabolomics, mounting number of metabolomic and proteomic studies attempt to identify the influence of storage conditions on urine analysis. This review presents an overview of the influence of storage conditions on urine analysis. |
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| Keywords: | Urine Storage Stability |
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