| 高原地区慢性阻塞性肺疾病患者IL-8、IL-17和MMP-9水平研究 |
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| 引用本文： | 朱燕,杨燕.高原地区慢性阻塞性肺疾病患者IL-8、IL-17和MMP-9水平研究[J].检验医学,2014(2):104-105,109. |
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| 作者姓名： | 朱燕 杨燕 |
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| 作者单位： | [1]青海省第五人民医院检验科,青海西宁810007 [2]石家庄市中心医院检验科,河北石家庄050000 |
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| 摘 要： | 目的探讨高原地区慢性阻塞性肺疾病(COPD)患者血液中白细胞介素-8(IL-8)、白细胞介素-17(IL-17)和基质金属蛋白酶(MMP-9)水平变化。方法采用酶联免疫吸附试验(ELISA)检测COPD急性加重期及缓解期患者、健康人血清IL-8、IL-17和MMP-9水平并进行统计学分析比较。结果 COPD急性加重期、缓解期患者血清IL-8、IL-17和MMP-9水平分别为(9.16±2.91)、(12.48±2.12)、(4.89±0.99)ng/L]、(6.53±1.96)、(5.76±1.98)、(3.24±0.97)ng/L]均高于健康对照组,差异有统计学意义(P0.05);急性加重期血清IL-8、IL-17和MMP-9检测水平也明显高于缓解期。结论 IL-8、IL-17和MMP-9水平检测可作为高原地区COPD诊断和观察疗效的理论指标。
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| 关 键 词： | 高原 COPD 白细胞介素-8 白细胞介素-1 7 基质金属蛋白酶-9 |
Research on IL-8,IL-17 and MMP-9 levels among patients with chronic obstructive pulmonary disease in high altitude area |
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| ZHU Yan,YANG Yan.Research on IL-8,IL-17 and MMP-9 levels among patients with chronic obstructive pulmonary disease in high altitude area[J].Laboratory Medicine,2014(2):104-105,109. |
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| Authors: | ZHU Yan YANG Yan |
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| Institution: | 1. Department of Clinical Laboratory, the Fifth People＇s Hospital of Qinghai Province, Qinghai Xining 810007, China; 2. Department of Clinical Laboratory, Shijiazhuang Central Hospital, Hebei Shijiazhuang 050000, China) |
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| Abstract: | Objective To investigate interleukin 8 （IL-8 ）,interleukin 1 7 （IL-1 7 ）and matrix metalloproteinase （MMP-9）levels among patients with chronic obstructive pulmonary disease （COPD）in high altitude area.Methods By enzyme-linked immunosorbent assay （ELISA ）,among COPD patients in acute exacerbation and remission and healthy subjects,the serum IL-8,IL-1 7 and MMP-9 levels were determined,analyzed and compared statistically. Results The IL-8,IL-1 7 and MMP-9 levels in COPD patients in acute exacerbation （9.1 6 ＆#177;2.91 ）,（1 2.48 ＆#177; 2.1 2）and （4.89 ＆#177;0.99）ng/L]and remission （6.53 ＆#177;1 .96）,（5.76 ＆#177;1 .98）and （3.24 ＆#177;0.97）ng/L]were higher than those in healthy controls,and the difference was statistically significant （P 〈0.05 ）.Those in acute exacerbation were significantly higher than those in remission.Conclusions The determinations of IL-8,IL-1 7 and MMP-9 levels can be used as the theory indices of COPD diagnosis in high altitude area. |
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| Keywords: | High altitude area Interleukin 8 Interleukin 17 Matrix metalloproteinase 9 |
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