儿童肾病综合征患者血清视黄醇结合蛋白4水平与氧化低密度脂蛋白的关系研究

目的探讨儿童肾病综合征(NS)患者血清视黄醇结合蛋白4(RBP4)水平的变化及其与氧化低密度脂蛋白(ox-LDL)的关系。方法分别检测118例NS患儿和45名健康体检儿童(正常对照组)血清RBP4水平,同时测定其血清ox-LDL、白蛋白(Alb)、血脂包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDL-C)及非高密度脂蛋白胆固醇(non HDL-C)]及肾功能指标尿素(Urea)、肌酐(Cr)],并做统计学分析。结果 NS组血清RBP4水平为(55.88±27.36)mg/L,明显高于正常对照组(30.61±8.68)mg/L](P0.01),且血清RBP4与ox-LDL、TC、TG、LDL-C、non HDL-C及Urea呈明显正相关相关系数(r)分别为0.30、0.35、0.25、0.29、0.32、0.26,P均0.01];进一步多元回归分析显示,NS组TC(β=0.62,P0.01)、Urea(β=0.26,P0.01)和ox-LDL(β=0.20,P0.05)水平共同影响了48.4%的RBP4的变化,且RBP4也是NS患儿ox-LDL水平的决定因素之一。结论 NS患儿血清RBP4水平明显升高。升高的RBP4与ox-LDL的增加有一定的关联,可能促进了NS的发生、发展。

Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome

Objective To investigate the relationship between the level change of serum retinol binding protein 4 （RBP4）and oxidized-low density lipoprotein（ox-LDL）in children with nephrotic syndrome（NS）.Methods The levels of serum RBP4 in 1 1 8 children with NS （NS group ） and 45 healthy children （healthy control group ） were determined respectively,the levels of ox-LDL,albumin （Alb ）,blood lipids total cholesterol （TC ）,triglyceride （TG）,low-density lipoprotein cholesterol （LDL-C）,high-density lipoprotein cholesterol （HDL-C）and non HDL-C] and renal function parameters urea and creatinine （Cr）]were determined simultaneously,and the results were analyzed statistically.Results The levels of serum RBP4 in NS group （55.88 ±27.36）mg/L]were significantly higher than those in healthy control group （30.61 ±8.68）mg/L]（P 〈0.01 ）.The levels of serum RBP4 were positively correlated with ox-LDL,TC,TG,LDL-C,non HDL-C and urea correlation coefficient （r）=0.30,0.35,0.25, 0.29,0.32 and 0.26,P〈0.01 ].Multiple linear regression analysis found that the changes of TC（β=0.62,P〈0.01 ）,urea（β=0.26,P〈0.01 ）and ox-LDL（β=0.20,P〈0.05）influenced the 48.4% of the change of RBP4.In addition,RBP4 was one of factors for the levels of ox-LDL in children with NS.Conclusions The levels of serum RBP4 in children with NS increase significantly,which are associated with the increase of ox-LDL,promoting the occurrence and development of NS.