MK-801 induced stereotypies in rats are decreased by haloperidol and increased by diazepam |
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Authors: | S Behrens W F Gattaz |
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Institution: | (1) Present address: Unit Neurobiology of Functional Psychoses, Central Institute of Mental Health, Mannheim, Federal Republic of Germany |
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Abstract: | Summary The effects of haloperidol and diazepam were investigated on stereotypies (wall contacts and turn rounds) induced by the non-competitive NMDA antagonist MK-801 in rats. Haloperidol (0.03, 0.10, 0.25 and 0.40mg/kg body weight) caused a dose-dependent antagonism whereas diazepam (3.0 and 5.0 mg/ kg) caused a dose-dependent agonism of the stereotypies induced by 0.30 mg/ kg MK-801 (all drugs given intraperitoneal). Conversely, diazepam (5.0 mg/kg) given alone reduced significantly the number of spontaneous wall contacts and turn rounds. The paradoxial stimulation of MK-801 induced stereotypies by diazepam could be explained by a shift between positive and negative corticostriatothalamic feedback loops envolving GABAergic neurons in favour of the former. |
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Keywords: | MK-801 NMDA-antagonists haloperidol diazepam |
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