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| PLGA纳米载体介导的端粒酶hTERT反义核酸对裸鼠肝癌移植瘤的影响 | |
| 引用本文： | 潘一峰,张阳德,王吉伟,张蕾,张洪. PLGA纳米载体介导的端粒酶hTERT反义核酸对裸鼠肝癌移植瘤的影响[J]. 中国现代医学杂志, 2006, 16(5): 664-665,668 |
| 作者姓名： | 潘一峰 张阳德 王吉伟 张蕾 张洪 |
| 作者单位： | 1. 卫生部纳米生物技术重点实验室,湖南,长沙,410008 2. 中南大学生物医学工程研究院,湖南,长沙,410008 3. 深圳市卫生局,广东,深圳,518020 |
| 摘 要： | 目的通过以PLGA纳米粒作为端粒酶hTERT反义核酸的载体，促进反义核酸对肝癌瘸组织的抑制。方法以HepG-2肝癌细胞和裸鼠建立肝癌移植瘤实验模型；观测瘸重和成瘤率；流式细胞仪检侧肿瘤细胞凋亡及细胞周期的特点。结果与对照组相比，治疗组肿瘤细胞凋亡数明显增加，细胞增殖受到抑制，肿瘤生长缓慢，出瘤时间推迟。结论以PLGA纳米粒作为端粒酶反义核酸的栽体，能显著延缓裸鼠肝癌移植瘤的发展，产生明显的疗效。 |
| 关 键 词： | 纳米载体 端粒酶hTERT反义核酸 肝癌移植瘤 |
| 文章编号： | 1005-8982（2006）05-0664-02 |
| 收稿时间： | 2006-02-10 |
| 修稿时间： | 2006-02-10 |
Influence of telomerase antisensenucleic acids carried by PLGA nanoparticles on transplanted liver tumor in athymic mouse |
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| PAN Yi-feng,ZHANG Yang-de,WANG Ji-wei,ZHANG Lei,ZHANG Hong. Influence of telomerase antisensenucleic acids carried by PLGA nanoparticles on transplanted liver tumor in athymic mouse[J]. China Journal of Modern Medicine, 2006, 16(5): 664-665,668 | |
| Authors: | PAN Yi-feng ZHANG Yang-de WANG Ji-wei ZHANG Lei ZHANG Hong |
| Affiliation: | 1. National Key Laboratory of Nanobiological Technology, Ministry of Health, Changsha, Hunan 410008, P.R.China; 2. Institute of Nanomedical Engineering, Changsha, Hunan 410008, P.R.China; 3. Health Administration of Shenzhen, Shenzhen, Guangdong 518020, P.R.China |
| Abstract: | [Objective] To improve inhibition of liver tumor through telomerase antisensenueleie acids carried by PLGA nanopartieles. [Methods] To establish animal model with transplanted liver tumor by using HepG-2 cells and athymie mouse. To investigate weight and emerging rate of tumor. To inspect apoptosis and cell cycle of tumor cell by fllow eytometry. [Result] Comparing with control group, apoptosis turnout cells increased in treated group and cell nndtiplieation was inhibited, growth of tumor slowed. [Conclusion] Telomerase antisensenueleie aeids earfled by PLGA nanopartieles could postpone development of liver tumor and create evid ctlrative effect. |
| Keywords: | nanoparticle telomerase antisensenucleic acids transplanted liver tumor |
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