| Loss of Anterior Chamber—Associated Immune Deviation druing Normal Pregnancy in Primates |
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| 引用本文： | Zhijie Li Guanghua Peng 等. Loss of Anterior Chamber—Associated Immune Deviation druing Normal Pregnancy in Primates[J]. 眼科学报, 1999, 15(1): 41-45 |
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| 作者姓名： | Zhijie Li Guanghua Peng 等 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (NNSFC)(No:39500158),Huo Yingdong Education Foundation in Ministry of Education,Natural Science Foundation of Guangdong Province (No.960208) |
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| 摘 要： | Purpose: We recently found that loss of anterior chamber-associated immune deviation was associated with normal pregnancy in rabbits. The purpose of this study is to further investigate whether the same events occurred in nonhuman primates. Methods: Mid-pregnant cynomolgus monkeys were randomly selected. Bovine serum albumin (BSA) was inoculated in anterior chamber of eyes of nonpregnant and mid-pregnant monkeys that were subsequently immunized with BSA in adjuvant. Delayed-type hypersensitivity (DTH) was assessed by skin challenge.Results: Non-pregnant monkeys of intracameral BSA proved able to acquire antigen-specific suppression of delayed-type hypersensitivity. By contrast, inoculation of BSA to anterior chamber of pregnant monkeys abolished the DTH-suppression effect. Conclusions: This is the first demonstration in primates that loss of anterior chamber-associated immune deviation occurred during normal pregnancy. The fluctuations of systemic hormone levels during normal pregnancy might influence l
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| 关 键 词： | 免疫特性 眼 免疫调节 灵长类 怀孕 |
Loss of Anterior Chamber-Associated Immune Deviation during Normal Pregnancy in Primates |
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| Z Li,G Peng,C Li. Loss of Anterior Chamber-Associated Immune Deviation during Normal Pregnancy in Primates[J]. Eye science, 1999, 15(1): 41-45 |
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| Authors: | Z Li G Peng C Li |
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| Affiliation: | Research Section of Ophthalmology, Institute of Tissue Transplantation & Immunology, Jinan University, Guangzhou 510632, China. |
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| Abstract: | Purpose: We recently found that loss of anterior chamber-associated immune deviation was associated with normal pregnancy in rabbits. The purpose of this study is to further investigate whether the same events occurred in nonhuman primates. Methods: Mid-pregnant cynomolgus monkeys were randomly selected. Bovine serum albumin (BSA) was inoculated in anterior chamber of eyes of nonpregnant and mid-pregnant monkeys that were subsequently immunized with BSA in adjuvant. Delayed-type hypersensitivity (DTH) was assessed by skin challenge.Results: Non-pregnant monkeys of intracameral BSA proved able to acquire antigen-specific suppression of delayed-type hypersensitivity. By contrast, inoculation of BSA to anterior chamber of pregnant monkeys abolished the DTH-suppression effect. Conclusions: This is the first demonstration in primates that loss of anterior chamber-associated immune deviation occurred during normal pregnancy. The fluctuations of systemic hormone levels during normal pregnancy might influence local immunoregu-lation within the eye. Eye Science 1999 ; 15 : 41 - 45. |
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| Keywords: | pregnancy anterior chamber-associated immune deviation immune privilege immune regulation |
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