DN患者血清内脂素和脂联素检测的临床意义

目的：探讨2型糖尿病肾病（DN）患者血清内脂素和脂联素水平的变化及意义。方法：应用放射免疫分析和酶联法测定41例DM2无肾病组和32例DN组患者血清内脂素和脂联素水平,并与35名正常人作比较。结果：DM2患者无论有无肾病组其血清内脂素水平均显著地高于正常人组（P〈0.01）,血清脂联素水平显著低于正常人组（P〈0.01）,两者呈明显的负相关（r=-0.4108,P〈0.01）。DN组血清脂联素水平高于DM2组。结论：血清内脂素、脂联素水平与DN的发生与发展密切相关,有重要的临床价值。

Clinical Significance of Determination of Changes of Serum Visfatin and Adiponectin Levels in Patients with Type 2 Diabetic Nephropathy

Objective To study the clinical significance of changes of serum visfatin and adiponectin levels in patients with type 2 diabetic nephropathy（DN）.Methods Serum visfatin（with ELISA） and serum adiponectin（with RIA） levels were determined in 41 cases of DM2 without nephropathy,32 cases of DN and 35 controls.Results Serum visfatin levels in the diabetic patients were significantly higher than those in controls（P〈0.01）,while the serum adiponectin levels were significantly lower than those in controls（P〈0.01）.Serum visfatin levels were significantly negatively correlated with those of serum adiponectin（r=-0.4108,P〈0.05）.The levels of serum adiponectin in patients with DN is higher than those in patients with DM2 but without nephropathy.Conclusion The development of type 2 diabetic nephropathy might be related to the levels of visfatin and adiponectin.