大蒜燕麦及其复合物对高脂大鼠血脂水平和血液流变特性的影响

目的　探讨大蒜、燕麦及其复合物对大鼠血脂代谢和血液流变学的影响。方法　选择健康大鼠60只,随机 分为5组,分别用普通饲料、高脂饲料、大蒜、燕麦及大蒜燕麦复合物干预8周,测定血脂含量及血液流变学。结果　用大 蒜、燕麦及大蒜燕麦复合物对高脂大鼠饲喂8周后,LGF、HGF和GOCF组的TC、TG、VLDL、LDL显著降低,HDL显著升高, 全血低、中、高切粘度、血浆粘度、HCT显著降低;饲喂高脂饲料组的大鼠则TC、TG、VLDL、LDL则进一步升高,HDL明显降 低。结论　大蒜和燕麦均具有降血脂和改善血液流变学的作用,而用低剂量的大蒜素和燕麦组合的复合饲料进行营养干 预,具有更加理想的降血脂和改善血液流变学的作用。

Effects of garlic and oat and their compounds on lipid level and hemorheology of hyperlipidemic rats

Objective To explore the effects of garlic and oat and their compounds on lipid metabolism and hemorheology of hyperlipidemic rats. Methods Sixty adult Wistar rats were randomly divided into five groups (12 in each group), and fed in different cages with basic forage, hyperlipid forage, low garlicin forage, high garlicin forage, and compound forage of garlicin and oat for 8 weeks. The blood lipid and hemorheology of hyperlipidemic rats were measured. Results After the rats were fed with low garlicin forage, high garlicin forage, and compound forage for 8 weeks, the levels of TC, TG, VLDL, and LDL decreased significantly, but HDL increased significantly. The contents of the high, middle and low blood viscosity, and plasma adhesion, blood reduction viscosity and hematocrit decreased significantly in low garlicin forage group, high garlicin forage group, compound forage of garlicin and oat group. In the normal forage group, these changes were not significant. In hyperlipid forage group, the contents of serum TG and TC, plasma VLDL-C and LDL-C increased significantly, but the contents of plasma HDL-C decreased significantly. Conclusion Garlic and oat may play a role in the decrease of lipid and ameliorate hemorheology, but low-dose compound forage of garlicin and oat may facilitate lipid metabolism and prevent hyperliemia and atherosclerosis.