|
|||||
|
|
Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep |
|
| Authors: | Giorgio Arpesella MD Ugo Carraro MD Piero M Mikus MD Franco Dozza MD Pierloca Lombardi MD Giuseppe Marinelli Sandra Zampieri SciBiol Abdul H El Messlemani Katia Rossini SciBiol Angelo Pierangeli MD |
| Affiliation: | aCardiovascular Surgery, The S. Orsola Hospital, University of Bologna, Bologna, Italy bC.N.R. Unit for Muscle Biology and Physiopathology and Department of Biomedical Sciences, University of Padova, Padova, Italy |
| Abstract: | Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity–rest could maintain partial transformation of the LD. Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months. Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation. Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |