CA125检测在活动性结核判定及疗效评估中的价值

目的　探讨血清CA12 5测定在活动性肺结核判定及疗效评估中的价值。方法　应用化学发光法分别对3 0例活动性肺结核治疗前、治疗后 2个月、4个月、6个月以及 3 0例非活动性肺结核和 3 0例健康体检者血清CA12 5进行测定。并对结果进行分析。结果　活动性肺结核治疗前血清CA12 5水平显著高于非活动性肺结核及健康体检者 (P <0 0 1)。活动性肺结核治疗前CA12 5水平显著高于治疗后各期测定值 (P <0 0 1) ,且治疗后血清CA12 5水平呈递减趋势。活动性肺结核治疗后 6个月血清CA12 5水平与非活动性肺结核比较无明显差异 ( P >0 0 5 )。结论　血清CA12 5测定可作为判定活动性肺结核及评估疗效的可靠指标

The value of serum CA125 in the evaluation of pulmonary tuberculosis activity and treatment effect

Objective To study the value of serum CA 125. in the evaluation of pulmonary tuberculosis activity and treatment effect.Method This study included 90 subjects who were divided into three groups.Group 1 consisted of 30 patients with active pulmonary tuberculosis.Group 2 included 30 patients with inactive pulmonary tuberculosis.There were 30 healthy subjects in group 3.While measurement of serum CA 125. level were performed only once in groups 2 and 3,CA 125. levels were measured four times in group 1 before and after the treatment.Result The serum CA 125. concentration in group 1 was higher than in the other groups (P<0.01),but there was no significant statistical difference between the values of groups 2 and 3 (P>0.05).CA 125. levels in group 1 showed a significant decrease after treatment (P<0.01).For estimation of the active of tuberculosis,the sensitivity and specificity of CA 125. were found to be 97.5% and 100% respectively at the 35U/L cut-off point.Conclusion The measurement of serum CA 125. level is beneficial in the determination of tuberculosis activity and in differentiation between active and inactive pulmonary tuberculosis and of higher value in the evaluation of treatment effect in active pulmonary tuberculosis.