| 细胞分裂周期蛋白25同源蛋白C与肿瘤放疗敏感性 |
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| 引用本文： | 尹亚超,李多杰. 细胞分裂周期蛋白25同源蛋白C与肿瘤放疗敏感性[J]. 国际肿瘤学杂志, 2014, 0(7): 511-514 |
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| 作者姓名： | 尹亚超 李多杰 |
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| 作者单位： | 尹亚超(233000,蚌埠医学院第一附属医院肿瘤放疗科)；李多杰(233000,蚌埠医学院第一附属医院肿瘤放疗科)； |
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| 摘 要： | 细胞分裂周期蛋白25同源蛋白C（Cdc25C）在真核细胞的有丝分裂中起重要调节作用。真核细胞中的G2-M进程主要由细胞周期蛋白依赖性激酶1（CDK1）-细胞周期蛋白B（cyclinB）复合物调控。CDK1-cyclinB复合物由Cdc25 C激活促进细胞从G2期进入M期，Cdc25 C活性是细胞周期进入M期的关键之一。提高Cdc25 C活性可促进G2-M期转变，去除电离辐射诱导的G2-M期阻滞，使损伤的DNA在未得到修复的情况下进入细胞分裂期，可导致细胞的增殖性死亡，而提高放疗敏感性。
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| 关 键 词： | Cdc25磷酸酶类 辐射耐受性 肿瘤 细胞周期 |
Research progress of cell division cycle 25 homolog C and tumor radiosensitivity |
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| Yin Yachao,Li Duojie. Research progress of cell division cycle 25 homolog C and tumor radiosensitivity[J]. Journal of International Oncology, 2014, 0(7): 511-514 |
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| Authors: | Yin Yachao Li Duojie |
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| Affiliation: | (Department of Radiotherapy, The First affiliated Hospital of Bengbu Medical College, Bengbu 233000, China) |
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| Abstract: | AsoneoftheCdc25phosphatasefamilymembers,Cdc25Cplaysanimportantroleinregu-lating mitosis of eukaryotic cells.In eukaryotic cells,CDK1-cell cycle protein B （CyclinB）compound mainly control the process of G2-M.The activity of Cdc25 C is the key in cell cycle into M phase.It activates CDK1-cyclinB complexes to promote cells from G2 to M phase .Improving Cdc25 C activity can promote the G2-M phase transition,and remove the G2-M phase retardation induced by ionizing radiation,preventing the damaged DNA from repaired into the phase of cell division,resulting in cell death caused by excessive cell proliferation, thus enhance radiosensitivity. |
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| Keywords: | Cdc25phosphatases Radiationtolerance Neoplasms Cellcycle |
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