Two new triterpenoids from Azadirachta indica and their insecticidal activity |
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| Authors: | Siddiqui Bina S Afshan Farhana Faizi Shaheen Naeem-Ul-Hassan Naqvi Syed Tariq Rajput M |
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| Affiliation: | H.E.J. Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Pakistan. bina@khi.comsats.net.pk |
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| Abstract: | Two new triterpenoids, 22,23-dihydronimocinol (1) and desfurano-6alpha-hydroxyazadiradione (2), were isolated from a methanolic extract of the fresh leaves of Azadirachta indica (neem) along with a known meliacin, 7alpha-senecioyl-(7-deacetyl)-23-O-methylnimocinolide. The structures of 1 and 2 were elucidated through spectral and chemical studies. Compounds 1 and 2 showed mortality for fourth instar larvae of the mosquito (Anopheles stephensi), with LC(50) values of 60 and 43 ppm, respectively. |
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