易卒中型肾血管性高血压大鼠基底动脉NPY能神经纤维的变化

本文用ABC免疫组化方法观察易卒中型肾血管性高血压大鼠高血压各时期脑基底动脉神经肽Y阳性神经纤维的变化。神经纤维定量结果显示:对照组神经肽Y能神经纤维多呈环状分布,而高血压组环状纤维减少,早、中期纤维密度与对照组无明显差异,在晚期,血管壁神经纤维多为纵行,密度明显降低,与早、中期及对照组差异均显著(P<0.01)。脑卒中症状观察结果显示:对照组及高血压组早、中期均无脑卒中发生,而高血压晚期大鼠均出现不同程度的脑卒中。提示:脑基底动脉神经肽Y能神经纤维密度降低与高血压晚期发生脑卒中可能有关。

THE CHANGES OF NPY-CONTAINING NERVES ON THE WALL OF BASILAR ARTERIES IN STROKE-PRONE RENOVASCULAR HYPERTENSIVE RATS

The purpose of this study is to observe the changes of NPY innervation of the basilar arteries in stroke -prone renovascular hypertensive rats(RHRSP) during the early, middle and late periods by immunohisto chemical technique. The results are as follows: in the control groups, the NPY - containing fibers encircled the wall of the basilar arteries, however, in the experimental groups, the circular fibers decreased but have no significant difference, compared with the control group or between the middle and early phase, and the distribution of fibers are longitudinal shape. In the late phase, the innervation in density decrease significantly (P<0. 01). Meanwhile, we observe that no stroke occurs in the early, middle phase in the experimental group and in the control group, but, numerous stroke appear in the late phase in the experimental group. The results in this experiment suggest that the decrease of innervation of the wall of the basilar arteries should be associated with the development of stroke.