肿瘤微环境相关17型辅助性T细胞

 17型辅助性T细胞（Th17）是近年来发现的一种不同于传统1型和2型的CD4+效应T细胞，该细胞是由初始T细胞前体分化而来。肿瘤可通过免疫微环境中部分细胞因子招募外周血中Th17细胞至肿瘤局部，而Th17的分化进程也受到肿瘤微环境的精细调控。Th17对肿瘤生长等恶性生物学行为具有促进及抑制的双向作用。对Th17的进一步深入研究，将为肿瘤免疫研究提供新的切入点。

Tumor microenvironment related type 17 T helper cells

Type 17 T helper cells (Th17) are novel subsets of CD4+ effector T cells discovered recently which are different from the traditional type 1 and type 2. They are mainly differentiated from initial T cell precursor. Tumor microenvironmental cytokines can recruit CD4+ Th17 cells from the peripheral blood into tumor sites. And the differentiation of Th17 cells is also affected by tumor microenvironmental factors. Tumor infiltrating Th17 cells play a dual role for tumor growth in both pro and anti tumourigenic processes. A further understanding of the activities of Th17 cells will provide a new breakthrough point for the researches of cancer immunotherapy.