常用抗肿瘤药物相关肺毒性

 抗肿瘤药物相关肺毒性是引起呼吸衰竭的重要原因之一，其临床表现主要为肺部炎症表现、过敏性反应、血管渗透性反应及肺血管疾病等，发病机制与药物对肺部的直接毒性、机体的免疫反应以及毛细血管通透性增加等有关。因其表现无特异性，故诊断时应以排除法除外其他肺部疾病，一旦诊断明确，立即停用相关抗肿瘤药物并及时予大剂量激素冲击治疗。如何降低抗肿瘤药物的肺毒性将成为今后抗肿瘤药物研究的一个重点。

Antineoplastic agents-induced pulmonary toxicity

Antineoplastic agents induced pulmonary toxicity is one of important reasons causing respiratory failure, which clinical manifestations are pulmonary inflammation, allergic reaction, vascular permeability reaction and pulmonary vascular disease. All of these may be caused by drug toxicity, immune response and increased capillary permeability and so on. Because of the nonspecific performance, it is important to exclude the other lung diseases. Once the diagnosis is clear, the antineoplastic agents should be immediately stopped and the patients should be timely administered high dose corticosteroid therapy. How to reduce the pulmonary toxicity induced by antineoplastic agents is becoming one of the future focuses about antineoplastic agents research. 