| 维生素D对肺癌的抑癌机制 |
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| 引用本文： | 康晓征,陈克能.维生素D对肺癌的抑癌机制[J].国际肿瘤学杂志,2012,39(8):594-597. |
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| 作者姓名： | 康晓征 陈克能 |
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| 作者单位： | 100142,北京大学肿瘤医院暨北京市肿瘤防治研究所胸外一科恶性肿瘤发病机制及转化研究教育部重点实验室 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金资助项目，北京市自然科学基金资助项目，首都医学发展科研基金资助项目，北京市卫生系统高层次卫生技术人才培养计划 |
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| 摘 要： | 维生素D及其代谢物在癌症中的作用日益受到重视，然而在肺癌中的探索尚浅。维生素D在肺癌中的抗增殖作用涉及3个重要环节，即维生素D受体、27羟化酶、24羟化酶。此外，维生素D还间接地影响胰岛素样生长因子、转化生长因子β及Wnt/β-catenin的信号传导而发挥抗癌作用。维生素D受体、27羟化酶及24羟化酶在正常肺组织及肺癌中的差异性表达，为揭示维生素D对肺癌的抑癌机制提供了线索并奠定了研究基础。
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| 关 键 词： | 维生素D 肺肿瘤 生物化学 基因表达 信号传导 |
Inhibition mechanism of vitamin D in lung cancer |
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| KANG Xiao-zheng
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CHEN Ke-neng.Inhibition mechanism of vitamin D in lung cancer[J].Journal of International Oncology,2012,39(8):594-597. |
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| Authors: | KANG Xiao-zheng CHEN Ke-neng |
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| Institution: | Key Laboratory of Carcinogenesis and Transformation Research (Ministry of Education), Thoracic Surgery Department 〖QX(Y15〗Ⅰ〖QX)〗, Peking University Cancer Hospital & Institute, Beijing 100142, China |
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| Abstract: | In recent years a large number of studies have been conducted to investigate the role of vitamin D and its metabolites in cancer. However, the picture for lung cancer is not clear at the present time. There are three integral components of the vitamin D pathway: the vitamin D receptor(VDR), CYP27B1 and CYP24A1. Besides, vitamin D inhibits the carcinogenesis of lung by indirectly influencing IGF signaling, TGF-β signaling, and Wnt/β-catenin signaling pathway. Their differential expressions in normal lung tissue and lung cancer offer clues and lay the foundation for research of the inhibitory function in lung cancer pathogenesis. |
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| Keywords: | Vitamin D Lung neoplasms Biochemistry Gene expression Signal transduction |
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