| 孕烷X受体与肿瘤多药耐药的相关性 |
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| 引用本文： | 乔恩奇,唐金海,吴建中. 孕烷X受体与肿瘤多药耐药的相关性[J]. 国际肿瘤学杂志, 2012, 39(7): 489-492 |
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| 作者姓名： | 乔恩奇 唐金海 吴建中 |
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| 作者单位： | 210009,南京医科大学附属江苏省肿瘤医院普外科 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | P-糖蛋白（P-gp）及其编码基因mdr1的过表达是肿瘤多药耐药（MDR）的经典机制。研究发现，孕烷X受体(PXR)可介导P-gp的表达，已证实PXR还具有抑制肿瘤细胞凋亡作用。因此，特异性地阻断PXR的活化可能是阻止MDR的新方法。
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| 关 键 词： | 抗药性, 肿瘤 P糖蛋白 孕烷X受体 |
Pregnane X receptor and tumor multidrug resistance |
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| QIAO En-qi , TANG Jin-hai , WU Jian-zhong. Pregnane X receptor and tumor multidrug resistance[J]. Journal of International Oncology, 2012, 39(7): 489-492 |
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| Authors: | QIAO En-qi TANG Jin-hai WU Jian-zhong |
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| Affiliation: | Department of General Surgery, Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009, China |
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| Abstract: | The overexpression of P-glycoprotein (P-gp) and its coding gene mdr1 is regarded as the classic mechanism of multidrug resistance (MDR). Recent studies find that pregnane X receptor (PXR) can mediate the expression of P-gp. It is confirmed that PXR can also inhibit apoptosis of tumor cells. Therefore, preventing the activation of PXR specifically may be a new method to prevent MDR. |
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| Keywords: | Drug resistance neoplasm P-glycbprotein Pregnane X receptor |
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