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COX-2和survivin蛋白表达与老年胃癌转移和预后的关系
引用本文:谷化平,尚培中.COX-2和survivin蛋白表达与老年胃癌转移和预后的关系[J].国际肿瘤学杂志,2012,39(5):387-390.
作者姓名:谷化平  尚培中
作者单位:1. 中国人民解放军第251医院病理科,张家口,075000
2. 中国人民解放军第251医院普外科,张家口,075000
摘    要: 探讨环氧合酶-2 (COX-2)和生存素(survivin)蛋白表达与老年胃癌临床病理特征和患者预后的关系.方法 应用免疫组化技术检测60例老年胃癌、30例异型增生和20例癌旁正常胃黏膜组织中COX-2和survivin蛋白表达,并结合肿瘤的病理学行为和临床随访资料进行分析。结果 在老年胃癌组织中COX-2和survivin表达阳性率分别为63.3%(38/60)和70.0%(42/60),均显著高于异型增生和正常胃黏膜组织(P<0.05)。COX-2和survivin表达与胃癌浆膜浸润、淋巴结转移和患者预后密切相关(P<0.05)。结论 COX-2和survivin表达与老年胃癌发生、转移和患者生存期密切相关,检测COX-2和survivin蛋白表达可作为判断老年胃癌预后的参考指标。

关 键 词:胃肿瘤  环氧化酶2  预后  生存素  

Expression of COX-2 and survivin protein in elderly patients with gastric cancer and its metastasis and prognosis
GU Hua-ping , SHANG Pei-zhong.Expression of COX-2 and survivin protein in elderly patients with gastric cancer and its metastasis and prognosis[J].Journal of International Oncology,2012,39(5):387-390.
Authors:GU Hua-ping  SHANG Pei-zhong
Institution:Department of Pathology, Chinese PLA 251 Hospital, Zhangjiakou 075000, China
Abstract:Objective To investigate the expression of adhesion molecules cyclooxygenase-2 (COX-2) and survivin protein in elderly patients with gastric cancer and their relationship with the pathological behavior and prognosis. Methods Immunohistochemical staining was used to detect the expression of COX-2 and survivin protein in 60 cases of elderly patients with gastric carcinoma, 30 eases of gastric epithelial dysplasia and 20 cases of normal gastric mueosa. The study was also combinedwith analysis of the pathological behavior and clinical follow-up survey of elderly patients with gastric carcinoma. Results The positive expression rates of COX2 and survivin protein in elderly patients with gastric carcinoma were 63.3% (38/60) and 70.0% (42/60) , respectively. The positive rates of COX-2 and survivin in elderly patients with gastric carcinoma were higher than that in epithelial dysplasia and normal gastric mueosa ( P 〈 0.05 ). The expression of COX-2 and survivin were closely related to the infiltration of serosa, metastasis of lymph node and prognosis of patients ( P 〈 0.05 ). Conclusion The expression of COX-2 and survivin are closely related to carcinogenesis, metastasis and survival time in elderly patients with gastric carcinoma. Detecting the expression of COX-2 and survivin may be prognostic indicators of elderly patients with gastric carcinoma.
Keywords:Stomach neoplasms  Cyclooxygenase 2  Prognosis  Survivin
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