| Dickkopf-1与骨转移癌 |
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| 引用本文： | 乔华,尤丽娜,范谷红.Dickkopf-1与骨转移癌[J].国际肿瘤学杂志,2012,39(8):626-628. |
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| 作者姓名： | 乔华 尤丽娜 范谷红 |
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| 作者单位： | 1. 200940,上海市第一人民医院宝山分院肿瘤科
2. 200940,上海市第一人民医院宝山分院科教科 |
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| 摘 要： | 研究显示DKK-1(dickkopf-1)异常与乳腺癌、前列腺癌、多发性骨髓瘤及神经母细胞瘤等骨转移的发生及治疗效果密切相关，亦与非小细胞肺癌密切相关。进一步进行血清DKK-1水平与常见肿瘤骨转移关系的大样本临床研究，对评价DKK-1作为骨转移癌临床生物标志物的价值、了解骨转移肿瘤机制具有重要临床意义。
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| 关 键 词： | 基因表达调控 肿瘤转移 肿瘤 骨组织 |
Dickkopf-1 and bone metastases |
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| QIAO Hua
,
YOU Li-na
,
FAN Gu-hong.Dickkopf-1 and bone metastases[J].Journal of International Oncology,2012,39(8):626-628. |
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| Authors: | QIAO Hua YOU Li-na FAN Gu-hong |
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| Institution: | Department of Oncology, Baoshan Branch, Shanghai First People′s Hospital, Shanghai 200940, China |
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| Abstract: | Recent studies show that the abnormalities of dickkopf-1 (DKK-1) are closely related to the bone metastasis and therapeutic effect of breast cancer, prostatic carcinoma, multiple myeloma, neuroblastoma and non-small cell lung cancer. Clinical researches of large sample on the relationships between serum DKK-1 concentration and malignant tumors bone metastases have important clinical significance for evaluating the value of DKK-1 as a clinical biological biomarker of bone metastases and understanding the tumor mechanisms of bone metastases . |
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| Keywords: | Gene expression regulation Neoplasm metastasis Neoplasms bone tissue |
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