| 蛋白酪氨酸磷酸酶SHP-1在细胞信号系统中的负调控作用 |
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| 引用本文： | 彭纲,曹如波,伍钢. 蛋白酪氨酸磷酸酶SHP-1在细胞信号系统中的负调控作用[J]. 国际肿瘤学杂志, 2012, 39(7): 485-488 |
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| 作者姓名： | 彭纲 曹如波 伍钢 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院肿瘤中心, 武汉,430022 |
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| 摘 要： | Src同源区2蛋白酪氨酸磷酸酶-1(SHP-1)主要表达在造血源性细胞胞质中，是改变胞内磷酸化水平的关键因子。SHP-1在不同的细胞中可产生不尽相同的胞内信号，从而发挥各种功能。
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| 关 键 词： | 蛋白酪氨酸激酶类 信号传导 免疫系统 造血系统 |
Negative effects of protein tyrosine phosphatase SHP-1 in cell signaling |
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| PENG Gang , CAO Ru-bo , WU Gang. Negative effects of protein tyrosine phosphatase SHP-1 in cell signaling[J]. Journal of International Oncology, 2012, 39(7): 485-488 |
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| Authors: | PENG Gang CAO Ru-bo WU Gang |
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| Affiliation: | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | SHP-1 is the protein tyrosine phosphatase which is mainly expressed in the cytoplasm of hematopoietic derived cells, and it is the key factor to change the levels of intracellular phosphorylation. SHP-1 can generate different intracellular signals in different cells, and it can play various functions. |
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| Keywords: | Protein-tyrosine kinases Signal transduction Immune system Hematopoietic system |
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