| 哺乳动物雷帕霉素靶蛋白抑制剂与肿瘤治疗 |
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| 引用本文： | 李欣,杨作成.哺乳动物雷帕霉素靶蛋白抑制剂与肿瘤治疗[J].国际肿瘤学杂志,2012,39(8):576-579. |
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| 作者姓名： | 李欣 杨作成 |
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| 作者单位： | 中南大学湘雅三医院儿科,长沙,410013 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 哺乳类动物雷帕霉素靶蛋白（mTOR）抑制剂的抗肿瘤作用已被熟知，传统的mTOR抑制剂包括雷帕霉素及其衍生物，早期已应用于临床。目前mTOR小分子抑制剂如磷脂酰肌醇激酶3 激酶（PI3K）/mTOR双重抑制剂、Torin1等陆续被发现在肿瘤治疗中有着独特的作用。
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| 关 键 词： | 肿瘤 抗肿瘤药 蛋白质丝氨酸苏氨酸激酶 |
Mammalian target of rapamycin inhibitors and tumor therapy |
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| LI Xin
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YANG Zuo-cheng.Mammalian target of rapamycin inhibitors and tumor therapy[J].Journal of International Oncology,2012,39(8):576-579. |
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| Authors: | LI Xin YANG Zuo-cheng |
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| Institution: | Department of Pediatrics, the Third Hospital of Xiangya Medical School, Central South University, Changsha 410013， China |
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| Abstract: | Mammalian target of rapamycin（mTOR） inhibitors have the anti tumor effect, which have been known early. The traditional mTOR inhibitors include rapamycin and its derivatives, which have been applied in clinical use early. Nowadays, some new small molecule inhibitors such as the PI3K/mTOR duel inhibitor, Torin1, one after another are found to play a unique role in the tumor therapy. |
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| Keywords: | Neoplasms Antineoplastic agents TOR serine-threonine kinases |
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