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MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1 |
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| Authors: | Zhuoan Cheng Shaobo Qiu Lin Jiang Anle Zhang Wenjing Bao Ping Liu Jianwen Liu |
| Affiliation: | 1. State Key Laboratory of Bioreactor Engineering & Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China 2. Longhua Hospital Affiliated to Shanghai University of traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China 3. The China Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning, 110032, People’s Republic of China |
| Abstract: | Myasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis. Here, we investigated the miRNAs expression profiles in MG for the first time and found that miR-320a was significantly downregulated in MG patients compared to normal healthy people. Meanwhile, pro-inflammatory cytokins in MG patients were overexpressed. Furthermore, we identified MAPK1 as a direct target of miR-320a. Downregulation of miR-320a induced the overexpression of pro-inflammatory cytokins through promoting COX-2 expression. This process was modulated by ERK/ NF-κB pathways. Taken together, our findings suggested that miR-320a could play a role in modulation of inflammatory cytokins production. |
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